Genome evolutionGenome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.
Human mitochondrial geneticsHuman mitochondrial genetics is the study of the genetics of human mitochondrial DNA (the DNA contained in human mitochondria). The human mitochondrial genome is the entirety of hereditary information contained in human mitochondria. Mitochondria are small structures in cells that generate energy for the cell to use, and are hence referred to as the "powerhouses" of the cell. Mitochondrial DNA (mtDNA) is not transmitted through nuclear DNA (nDNA). In humans, as in most multicellular organisms, mitochondrial DNA is inherited only from the mother's ovum.
ConjectureIn mathematics, a conjecture is a conclusion or a proposition that is proffered on a tentative basis without proof. Some conjectures, such as the Riemann hypothesis (still a conjecture) or Fermat's Last Theorem (a conjecture until proven in 1995 by Andrew Wiles), have shaped much of mathematical history as new areas of mathematics are developed in order to prove them. Formal mathematics is based on provable truth.
De novo gene birthDe novo gene birth is the process by which new genes evolve from DNA sequences that were ancestrally non-genic. De novo genes represent a subset of novel genes, and may be protein-coding or instead act as RNA genes. The processes that govern de novo gene birth are not well understood, although several models exist that describe possible mechanisms by which de novo gene birth may occur. Although de novo gene birth may have occurred at any point in an organism's evolutionary history, ancient de novo gene birth events are difficult to detect.
Beal conjectureThe Beal conjecture is the following conjecture in number theory: If where A, B, C, x, y, and z are positive integers with x, y, z ≥ 3, then A, B, and C have a common prime factor. Equivalently, The equation has no solutions in positive integers and pairwise coprime integers A, B, C if x, y, z ≥ 3. The conjecture was formulated in 1993 by Andrew Beal, a banker and amateur mathematician, while investigating generalizations of Fermat's Last Theorem. Since 1997, Beal has offered a monetary prize for a peer-reviewed proof of this conjecture or a counterexample.
Goldbach's conjectureGoldbach's conjecture is one of the oldest and best-known unsolved problems in number theory and all of mathematics. It states that every even natural number greater than 2 is the sum of two prime numbers. The conjecture has been shown to hold for all integers less than 4e18, but remains unproven despite considerable effort. On 7 June 1742, the German mathematician Christian Goldbach wrote a letter to Leonhard Euler (letter XLIII), in which he proposed the following conjecture: Goldbach was following the now-abandoned convention of considering 1 to be a prime number, so that a sum of units would indeed be a sum of primes.
DNADeoxyribonucleic acid (diːˈɒksᵻˌraɪboʊnjuːˌkliːᵻk,_-ˌkleɪ-; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life.
