Publication

Effects of Tissue-­Level Ductility on Trabecular Bone Strength

Frédéric Edouard Juillard
2011
Student project
Abstract

Osteoporosis is one of the most common skeletal diseases that lead to an accelerated bone loss due to an imbalance in bone turnover. This low bone mass and degraded bone microarchitecture cause a reduction in mechanical properties and an associated increase in fracture risk. If individual trabeculae become more brittle with aging, disease, or drug treatment, how does that influence the strength of the overall trabecular bone? This multi-scale issue, which relates energy absorption or tissue ductility at one scale to load-carrying capacity or strength at a higher scale, is particularly relevant in osteoporosis applications since it is well known that aging and drug treatments can influence tissue-level ductility. However, the link between tissue ductility and apparent-level strength for trabecular bone is poorly understood and thus is it not currently possible to infer how known changes in tissue ductility translate into the higher scale and more clinically relevant changes in trabecular strength. To provide insight into this issue, our goal in this study was to determine how trabecular strength is altered when the tissue is changed from perfectly brittle to perfectly ductile – the two extremes of possible tissue-level ductility. The results show that overall trabecular strength can vary two-fold if the tissue is entirely brittle compared to entirely ductile. The comparison with the experimental data suggests that at low bone volume fraction, real variations in tissue ductility could be important since the real behavior is situated between the ductile and brittle behaviors. If so, this implies that future studies assessing the structural consequence of changes in tissue-level ductility need to consider the bone volume fraction. Our analyses are unique since they are the first to account for the complex 3D geometric detail of real trabecular microarchitecture and this study is the first to mechanistically link tissue-level ductility, a potentially important aspect of tissue material behavior, to the apparent-level strength, which is relevant clinically.

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Ontological neighbourhood
Related concepts (35)
Bone
A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions. Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue.
Osteoporosis
Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone sterility, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly. Bones that commonly break include the vertebrae in the spine, the bones of the forearm, and the hip. Until a broken bone occurs there are typically no symptoms. Bones may weaken to such a degree that a break may occur with minor stress or spontaneously.
Bone fracture
A bone fracture (abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a partial or complete break in the continuity of any bone in the body. In more severe cases, the bone may be broken into several fragments, known as a comminuted fracture. A bone fracture may be the result of high force impact or stress, or a minimal trauma injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, osteopenia, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture.
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