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Imaging based optofluidic interferometer on a chip

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We propose and experimentally demonstrate an integrated hybrid optical fiber sensing technique that combines distributed Raman-based temperature measurements with a time-domain approach for FBG dynamic interrogation using a shared optical source and receiv ...

2012

Optofluidic membrane interferometer: An imaging method for measuring microfluidic pressure and flow rate simultaneously on a chip

Demetri Psaltis, Wuzhou Song

We present a novel image-based method to measure the on-chip microfluidic pressure and flow rate simultaneously by using the integrated optofluidic membrane interferometers (OMIs). The device was constructed with two layers of structured polydimethylsiloxa ...

American Institute of Physics2011

Suspended SU-8 structures for monolithic microfluidic channels

Martinus Gijs, Thomas Lehnert, Sébastien Jiguet, Yves Moser, Riccardo Forti

SU-8 photoresist is commonly used in the field of microfabrication as structural material or for molding of microfluidic devices. One major limitation, however, is the difficulty to process partially freestanding SU-8 structures or monolithic closed caviti ...

Springer-Verlag2011

Optofluidic lock-in spectroscopy on a chip

Demetri Psaltis, Wuzhou Song

We introduce for the first time the implementation of optofluidic lock-in spectroscopy of sub-nanoliter analyte on a microfluidic chip. Two methods, spatial modulation and pneumatic modulation with integrated optofluidic modulator, were demonstrated. (C) 2 ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

Imaging based optofluidic air flow meter with polymer interferometers defined by soft lithography

Demetri Psaltis, Wuzhou Song

We present an optofluidic chip with integrated polymer interferometers for measuring both the microfluidic air pressure and flow rate. The chip contains a microfluidic circuit and optical cavities on a polymer which was defined by soft lithography. The pre ...

2010

Investigation of hot roller embossing for microfluidic devices

Nico de Rooij

Abstract Microfluidics for most bio-related diagnostic applications typically requires single usage disposable chips to avoid bio-fouling and cross-contamination. Individual piece-wise manufacturing of polymeric microfluidic devices has been widely employe ...

2010

Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme

We use magnetic microbeads, which are magnetically self-assembled in chains in a microfluidic chip, as reaction substrates to implement two different sandwich immunoassay protocols for the detection of mouse monoclonal target antibodies. The magnetic chain ...

Springer-Verlag2009

Separation, detection and quantification of biomolecules in lab-on-a-chip systems

Frédéric Lacharme

Since the introduction of the of Micro Total Analysis Systems concept in 1990, important progress in microfluidic analytical systems has been realized. In many cases, microfluidic systems have shown improved analytical performances over classical methods, ...

EPFL2008

Microfluidic chip for cells' electrofusion

Albora De Pablo Pena

[...] During this project, the fusion feasibility of chips produced for other applications have been tested and some critical fusion parameters have been defined. Then, with the help of FEM simulations, a new chip design has been proposed to overcome the p ...

2008

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We report on an innovative approach to on-chip detection of single fluorescently-labeled magnetic micro-particles by means of Single Photon Avalanche Diode (SPAD) arrays. Our system enables particle separation through magnetic actuation and highly sensitiv ...

2008