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Magnetic Particle Handling In Microfluidic Systems

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Quadrupolar magnetic actuation of superparamagnetic particles for enhanced microfluidic perfusion

Martinus Gijs, Thomas Lehnert, Yves Moser

We report on the magnetic actuation of superparamagnetic particles in a microfluidic channel. The formation of a highly confined and dynamic plug of particles extending over the cross section of the microchannel is enabled by superposing a static and a tim ...

2009

Purification of magnetic microparticles was demonstrated, with a purification efficiency of (72±14) % at a flow rate of 3 μl/min, in a microfluidic chip using a rotational magnetic system under continuous flow conditions. The rotation of a periodically arr ...

Elsevier2009

Magnetic microparticles and their application in bioanalytical microfluidic systems have been steadily gaining interest in recent years. This progress is fueled by the comparatively large and long range magnetic forces that can be obtained independently of ...

EPFL2008

This thesis reports on the integration of continuous-flow cell separation method for lab-on-a-chip applications. Cell separation methods are widely used in biology to prepare samples prior to analysis. There is a need for a highly sensitive separation meth ...

EPFL2008

Focusing and continuous separation of cells in a microfluidic device using lateral dielectrophoresis

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre, Randoald Müller

We have fabricated a microfluidic device based on a novel geometrical arrangement of lateral metal electrodes and a patterned insulator. Our device combines the concept of insulator-based “electrodeless” dielectrophoresis with multiple frequencies to achie ...

2008

We present a DC magnetohydrodynamic (MHD) pump as component of a nuclear magnetic resonance (NMR) microfluidic chip. This is the first time that MHD pumping in an NMR environment was observed and demonstrated. This chip generates a maximum flow rate of 1.5 ...

2007

Optical trapping and micromanipulation of biological objects in microfluidic channels

Marinela Gjoni Boillat

The main aim of this project was to develop novel concepts for miniaturization of bioanalytical techniques for investigating biomolecular interactions. We used optical tweezers to selectively address individual biological objects in microfluidic channels. ...

EPFL2007

Focusing and continuous separation of cells in a microfluidic device using lateral dielectrophoresis

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre, Randoald Müller

We have fabricated a microfluidic device based on a novel geometrical arrangement of lateral metal electrodes and a patterned insulator. We have used the concept of insulator-based "electrodeless" dielectrophoresis to achieve focusing and continuous separa ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2007

Microfabricated NMR-probes for the analysis of living cells

Microfabricated probes for Nuclear Magnetic Resonance (NMR) spectroscopy of living cells in very small quantities have been developed in this thesis. These microprobes are based on two different sample interfaces: Channel microprobes, which confine a stack ...

EPFL2006

Magnetically actuated micropumps

Christophe Yamahata

"Lab-On-a-Chip" (LOC) systems are intended to transpose complete laboratory instrumentations on the few square centimetres of a single microfluidic chip. With such devices the objective is to minimize the time and cost associated with routine biological an ...

EPFL2005