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Spot Identification and Quality Control in Cell-Based Microarrays

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Virtual metrology applied to milling process

Paul Arthur Adrien Pierre Dreyfus

Production quality and process efficiency are the two main drivers that lead any industrial strategy. To ensure product quality, a duality historically existed between two approaches, namely batch sampling and systematic sampling. In batch sampling, the ba ...

EPFL2022

Developing new tools to study and program cell fate at the single-cell level

Marjan Biocanin

Single-cell transcriptomics (scRNA-seq) started a technological revolution in biology by enabling through the plethora of methods to assess a molecular state of the cell on systems level without the strict necessity of the prior knowledge of the cell state ...

EPFL2021

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Kristin Schirmer, Anze Zupanic

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...

AMER CHEMICAL SOC2020

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In the competitive market of manufacturing, quality is a criterion of primary importance in order to win market share. Quality improvement must be coupled with performance point of view. Lean Manufacturing, Six Sigma, Lean Six Sigma, Total Quality Manageme ...

2020

Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial response, a fraction of cases manifest progression to castration-resistant prostate cancer. PCa recurrence is possibly due to androgen-independent cancer stem c ...

AMER ASSOC CANCER RESEARCH2018

The surface chemistry at the DNA recognition and binding interface plays an important role in determining the performance of DNA microarrays and DNA biosensors. Surface-initiated controlled radical polymerization (SI-CRP) reactions represent a powerful too ...

2015

From Data Quality to Big Data Quality

Gianluigi Viscusi

This article investigates the evolution of data quality issues from traditional structured data managed in relational databases to Big Data. In particular, the paper examines the nature of the relationship between Data Quality and several research coordina ...

2015

Essential in biomedical research is the necessity of gathering statistically relevant data about large populations of specific biological entities, e.g. organisms, cells or molecules, while preserving detailed information about each single entity under in ...

EPFL2015

Antibody microarrays are powerful and high-throughput tools for screening and identifying tumor markers from small sample volumes of only a few microliters. Optimization of surface chemistry and spotting conditions are crucial parameters to enhance antibod ...

Amer Chemical Soc2013

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Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, labe ...

2011