Publication
Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration
Related publications (49)
Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Rolf Gruetter, Hongxia Lei, Jonathan Paz Montoya, Marc Moniatte, Ana Francisca Leal Silva Soares
Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...
Wiley-Blackwell2017Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage
Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...
Frontiers Media Sa2016Metabolic Alterations Associated to Brain Dysfunction in Diabetes
From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although ...
Int Soc Aging & Disease2015Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans
Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen
Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...
American Diabetes Association2015TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation
Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols
The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...
American Society for Clinical Investigation2014Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection
Giovanni De Micheli, Sandro Carrara, Lucia Grassi
New advancements in the management of type I diabetic patients (T1DM) call for a new generation of monitoring systems based upon an array of metabolic biosensors including sensors for insulin detection. Blood insulin values are always less than 270 pM; the ...
2013JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study
For type 1 Diabetes, insulin injection therapy is the most used treatment today, and insulin pumps are surely the most accurate therapeutic strategy. The insulin use temperature has to not exceed 37°C to prevent unwanted degradation and loss of function. T ...
2011Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity
Johan Auwerx, Hiroyasu Yamamoto
Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte bi ...
2011Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia
Daniel Constam, Marine Marie Kraus, Anne Grapin-Botton
Bicaudal C homologue 1 (Bicc1) knockout in mice causes polycystic kidney disease and pancreas development defects, including a reduction in insulin-producing β-cells and ensuing diabetes. We therefore screened 137 patients with renal abnormalities or assoc ...
2011High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets
Rolf Gruetter, Riikka Immonen, Christine Nabuurs
OBJECTIVE-We studied whether manganese-enhanced high-field magnetic resonance (MR) imaging (MEHFMRI) could quantitatively detect individual islets in situ and in vivo and evaluate changes in a model of experimental diabetes. ...
2011