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Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections

Related publications (34)

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Advanced Neurotechnologies for the Restoration of Motor Function

Silvestro Micera, Friedhelm Christoph Hummel

Stroke is one of the leading causes of long-term disability. Advanced technological solutions ("neurotechnologies'') exploiting robotic systems and electrodes that stimulate the nervous system can increase the efficacy of stroke rehabilitation. Recent stud ...

CELL PRESS2020

Throughout species, including mice and humans, we all have to make decisions to fulfill our fundamentals needs: eat, drink, explore, communicate, reproduce... To make those decisions, we have to collect informations from the surrounding world and to proces ...

EPFL2018

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The present disclosure relates to a neuromodulation and/or neurostimulation system comprising at least the following components: at least one sensing unit, at least control unit, at least one stimulation unit, at least one Central Nervous System (CNS) stim ...

2018

On the Use of Intraneural Transversal Electrodes to Develop Bidirectional Bionic Limbs

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini

The development of more effective approaches for controlling dexterous hand prostheses is an important area of research currently addressed by several groups with the aim of improving the quality of life of amputees. It is particularly important to establi ...

Springer International Publishing Ag2017

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

Amélie Anne Guex

Neuroprosthetic systems are designed to interface with the nervous system, for the replacement or restoration of damaged functions in the motor and/or sensory systems. In order to have an efficient communication with the nervous tissue leading to optimized ...

EPFL2017

Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat

Marco Bonizzato

Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...

EPFL2017

The Quest for a Bionic Hand

Silvestro Micera

Replacing a missing upper limb with a functional one is an ancient need and desire. The need for a versatile prosthetic limb with intuitive motor control and realistic sensory feedback is huge and its development is absolutely necessary for the near future ...

Springer International Publishing Ag2017

Framework for the Development of Neuroprostheses: From Basic Understanding by Sciatic and Median Nerves Models to Bionic Legs and Hands

Stanisa Raspopovic, Francesco Maria Petrini, Giacomo Valle, Marek Zelechowski

Neuroprostheses based on electrical stimulation are becoming a therapeutic reality, dramatically improving the life of disabled people. They are based on neural interfaces that are designed to create an intimate contact with neural cells. These devices spe ...

Ieee-Inst Electrical Electronics Engineers Inc2017

SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the re ...

Academic Press Inc Elsevier Science2017

A hybrid computational model to predict chemotactic guidance of growth cones

Silvestro Micera

The overall strategy used by growing axons to find their correct paths during the nervous system development is not yet completely understood. Indeed, some emergent and counterintuitive phenomena were recently described during axon pathfinding in presence ...

Nature Publishing Group2015