Structural Variation-Associated Expression Changes Are Paralleled by Chromatin Architecture Modifications
Graph Chatbot
Chat with Graph Search
Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.
DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.
KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...
A review. Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole was recently isolated in trace amts. from cya ...
One of the central questions in eukaryotic transcription is how activators can transmit their signal to stimulate gene expression in the context of chromatin. The multisubunit SAGA coactivator complex has both histone acetyltransferase and deubiquitination ...
Epigenetic alterations during tumor formation and progression have become an increasingly important aspect of cancer biology. Loss of global methylation at histone H4 lysine 20, mediated by the Suv4-20 HMTases, and loss of methylation at histone H3 lysine ...
Li a-(dimethylamino)alkoxides resulting from the nucleophilic addn. of an organolithium reagent to DMF are basic enough to deprotonate alkyltriphenylphosphonium salts suspended in THF. The aldehydes, liberated by the spontaneous decompn. of the resulting a ...
Multiprotein bridging factor (MBF-1) is a cofactor that was first described for its capacity to modulate the activity of fushi tarazu factor 1, a nuclear receptor originally implicated in Drosophila development. Recently, it has been shown that human MBF-1 ...