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Meta-analysis of incomplete microarray studies

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DESI mock challenge Halo and galaxy catalogues with the bias assignment method

Cheng Zhao, Ginevra Favole, Yu Yu

Context. We present a novel approach to the construction of mock galaxy catalogues for large-scale structure analysis based on the distribution of dark matter halos obtained with effective bias models at the field level. Aims. We aim to produce mock galaxy ...

EDP SCIENCES S A2023

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Kristin Schirmer, Anze Zupanic

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...

AMER CHEMICAL SOC2020

Mechanistic insights into AMP-activated protein kinase-dependent gene expression

Caterina Collodet

AMP-activated protein kinase (AMPK) is a fundamental enzyme that controls energy homeostasis, through orchestrating the cellular response to a reduction in energy availability. Under conditions of cellular energy stress AMPK senses the decrease in ATP leve ...

EPFL2019

A toolkit for multi-scale mapping of the solar energy-generation potential of buildings in urban environments under uncertainty

Marilyne Andersen, Giuseppe Peronato, Parag Rastogi

Many municipalities and public authorities have supported the creation of solar cadastres to map the solar energy-generation potential of existing buildings. Despite advancements in modelling solar potential, most of these tools provide simple evaluations ...

2018

In many population genetic problems, parameter estimation is obstructed by an intractable likelihood function. Therefore, approximate estimation methods have been developed, and with growing computational power, sampling-based methods became popular. Howev ...

De Gruyter2017

ODE parameter estimation through a runner's model application

The monitoring of sports' performance has become increasingly popular in the past years. For instance, high precision measurement of runners' speed, foot pace and heart beat are available among others. Usually, coaches are interested in summary statistics ...

2016

This thesis looks at efficient information processing for two network applications: content delivery with caching and collecting summary statistics in wireless sensor networks. Both applications are studied under the same paradigm: function computation ove ...

EPFL2015

Multiple comparisons procedures for complex dependent data with application to study human brain complex network properties

Djalel Eddine Meskaldji

We consider the problem of testing positively dependent multiple hypotheses, assuming that prior information about the dependence structure is available. We propose two-step multiple comparisons procedures that exploit the prior information of the dependen ...

2015

Meta-analysis of microarray studies to produce an overall gene list is relatively straightforward when complete data are available. When some studies lack information, providing only a ranked list of genes, for example, it is common to reduce all studies t ...

EPFL2014

Identification of HMX1 target genes: A predictive promoter model approach

Purpose: A homozygous mutation in the H6 family homeobox 1 (HMX1) gene is responsible for a new oculoauricular defect leading to eye and auricular developmental abnormalities as well as early retinal degeneration (MIM 612109). However, the HMX1 pathway rem ...

Molecular Vision2013