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The neural cell adhesion molecule (NCAM) plays a key role in synaptic plasticity and memory formation. We have recently developed a synthetic peptide, termed C3d, which, through the binding to the first, N-terminal immunoglobulin-like (Ig) module in the ex ...
We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essenti ...
Down syndrome (DS) is the most frequent cause of mental retardation in adults and children. It has been proposed that cognitive disabilities associated with DS may be ascribed to neurogenesis impairment during both development and adulthood. This view is s ...
Contextual fear conditioning under training conditions involving high stressor intensities has been proposed as an animal model for traumatic memories. The strength of memory for this task has been related to the intensity of the conditioning stressor and ...
The human mind is continuously involved in "projecting" the self in time in order to process past memories and predict future occurrences. "Self-projection" in time involves episodic and spatial memory, relying on medial-temporal structures, but also engag ...
Since the original publication of Martin Hellman's cryptanalytic time-memory trade-off, a few improvements on the method have been suggested. In all these variants, the cryptanalysis time decreases with the square of the available memory. However, a large ...
Down syndrome (DS) is the most frequent cause of cognitive disability in children and adults. It has been reported that defects in neurogenesis occur both during development and adulthood and possibly underlie cognitive dysfunction associated with DS. Rece ...
Stress and glucocorticoids (GCs) can facilitate memory formation. However, the molecular mechanisms mediating their effects are largely unknown. alpha-Amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) trafficking has been implicat ...
The neural cell adhesion molecule (NCAM) plays a pivotal role in neural development, regeneration, synaptic plasticity, and memory processes. P2 is a 12-amino-acid peptide derived from the second immunoglobulin-like (Ig) module of NCAM mediating cis-homoph ...
The capability to learn from experience is a key property for a visual recognition algorithm working in realistic settings. This paper presents an SVM-based algorithm, capable of learning model representations incrementally while keeping under control memo ...
