Publication
The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function
Related publications (45)
First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting
Biranche Tandon, Nicolas Tissot
In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...
Weinheim2024Environment rather than breed or body site shapes the skin bacterial community of healthy sheep as revealed by metabarcoding
Christof Holliger, Alexander Mathis, Emmanuelle Rohrbach, Laetitia Janine Andrée Cardona
Background: The skin is inhabited by a variety of micro-organisms, with bacteria representing the predominant taxon of the skin microbiome. In sheep, the skin bacterial community of healthy animals has been addressed in few studies, only with culture-based ...
2023Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine
Corinne Scaletta, Sandra Jaccoud, Philippe Abdel Sayed, Nathalie Hirt-Burri, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent, Joachim Meuli, Axelle Thomas
Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...
MDPI2023Wireless soft microscale actuators and robotic devices to study mechanobiology
Raquel Filipa Penacho Parreira
Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...
EPFL2021Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning
Hubert Girault, Horst Pick, Natalia Gasilova, Andreas Stephan Lesch, Milica Jovic, Tzu-En Lin, Yingdi Zhu
Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detec ...
2021A new paradigm for leprosy diagnosis based on host gene expression
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo
Author summary Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus still uncultiv ...
PUBLIC LIBRARY SCIENCE2021Skin cell analysis
Hubert Girault, Horst Pick, Andreas Stephan Lesch, Milica Jovic, Tzu-En Lin, Yingdi Zhu
The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...
2020The Delivery of alpha 1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore
Human alpha 1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide ...
FRONTIERS MEDIA SA2020Surface and bulk stresses drive morphological changes in fibrous microtissues
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas
Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...
2019Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine
Priscilla Suhasna Maithili Briquez
Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...
EPFL2016