Publication

Copper-Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles

Qian Wang, Jieping Zhu, Ala Bunescu
2014
Journal paper

Abstract

A copper-promoted oxyalkylation of alkenes with alkylnitriles has been developed. The protocol provides rapid access to phthalides (g-lactones) or isochromanones (d-lactones) via the formation of a C(sp3)C(sp3) and a C(sp3)O bond with the generation of up to two quaternary carbon atoms. Mechanistic studies suggest that this reaction is initiated by the formation of the C(sp3)C(sp3) bond rather than the C(sp3)O bond. Catalytic conditions were subsequently developed using carboxylic acid as an internal nucleophile.

Official source

https://infoscience.epfl.ch/record/202671?ln=en

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Copper-Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles

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Organocatalytic Enantioselective Pictet–Spengler Reaction of α‐Ketoesters: Development and Application to the Total Synthesis of (+)‐Alstratine A

Electro- and photochemical H-2 generation by Co(ii) polypyridyl-based catalysts bearing ortho-substituted pyridines

Taming the radical cation intermediate enabled one-step access to structurally diverse lignans