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Structure of viral membrane-penetrating machines by electron cryo-microscopy and tomography
Related publications (58)
Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein
Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the end ...
PUBLIC LIBRARY SCIENCE2023The tip protein PAAR is required for the function of the type VI secretion system
Bacteria are constantly competing to colonize crowded ecological niches, such as the human gut. The type VI secretion system (T6SS) is a critical bacterial weapon in this warfare. It resembles a crossbow with a poisoned arrow allowing bacteria to inject to ...
Washington2023Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions
Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...
EPFL2022Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Henning Paul-Julius Stahlberg, Dongchun Ni, Iwan Zimmermann, Denis Bucher
Lipopolysaccharides are major constituents of the extracellular leaflet in the bacterial outer membrane and form an effective physical barrier for environmental threats and for antibiotics in Gram-negative bacteria. The last step of LPS insertion via the L ...
2022Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae
Melanie Blokesch, David William Adams, Milena Jadwiga Jaskolska
Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of mobile genetic elements—in particular bacteriophages and plasmids—the ability to share genes within and across species underpins the exceptional adaptability o ...
2022Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water
Enteroviruses are ubiquitous contaminants of surface waters, yet their fate in presence of microbial congeners is poorly understood. In this work, we investigated the inactivation of Echovirus-11 (E11) and Coxsackievirus-A9 (CVA9) by bacteria isolated from ...
2022Functional and structural characterization of Serratia marcescens ExbB: determinants of the interaction with HasB/TonB
ExbBD is part of a cytoplasmic membrane molecular motor driven by the proton-motive force. It belongs to the larger family of motors involved in nutriment import across the outer membrane of Gram-negative bacteria (ExbBD), flagellar rotation (MotAB) or lat ...
2021Structure and Function of the T4 Spackle Protein Gp61.3
The bacteriophage T4 genome contains two genes that code for proteins with lysozyme activity-e and 5. Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which is requ ...
MDPI2020Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach
The characterization of biological interfaces is widely recognized as one of the main challenges for modern biology. In particular, biological membranes are nowadays known to be an active environment that allows membrane proteins to perform their work and ...
EPFL2020Scratching the Surface: Bacterial Cell Envelopes at the Nanoscale
The bacterial cell envelope is essential for viability, the environmental gatekeeper and first line of defense against external stresses. For most bacteria, the envelope biosynthesis is also the site of action of some of the most important groups of antibi ...
AMER SOC MICROBIOLOGY2020