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A versatile clearing agent for multi-modal brain imaging

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Functional and Structural Imaging with Optical Coherence Microscopy

Arno Pino Bouwens

Fluorescence microscopy techniques are well established research tools and have proven their use in a large variety of biomedical applications. Microscopic molecular contrast is achieved by imaging fluorescent dyes that bind specifically to a molecule of i ...

EPFL2013

IMAGING The fog clears

Demetri Psaltis

A technique has been developed to image a fluorescent object hiding behind a light-scattering screen without the need for a detector behind the screen. The approach could find applications in imaging biological tissue. ...

Nature Publishing Group2012

Extended Focus Optical Coherence Microscopy

Martin Villiger

Optical coherence tomography (OCT) is an interferometric imaging technique that can provide depth resolved cross-sectional views of biological tissue. OCT employs light with low temporal and yet high spatial coherence. The sample is illuminated point by po ...

EPFL2010

Advanced phase-contrast imaging using a grating interferometer

Christian David, Marco Stampanoni

Phase-sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption-based imaging, and therefore new and otherwise inaccessible information. Differential phase-contrast (DPC) imaging, which uses a grating interfe ...

2009

Towards in vivo small animal imaging

Theo Lasser, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Fourier domain Optical coherence microscopy (FDOCM) offers excellent sensitivity and high axial resolution to image the structure of biological tissue. The depth information is extracted in parallel and allows very high volume acquisition rates. An illumin ...

2008

Extended focus Fourier domain optical coherence microscopy assists developmental biology

Theo Lasser, Cathrin Brisken, Rainer Leitgeb

We present a novel detection scheme for Fourier domain optical coherence microscopy (FDOCM). A Bessel-like interference pattern with a strong central lobe was created with an axicon lens. This pattern was then imaged by a telescopic system into the sample ...

SPIE2007

Extended focus Fourier domain optical coherence microscopy assists developmental biology - art. no. 66271H

Theo Lasser, Cathrin Brisken, Rainer Leitgeb

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2007

Phase-locked Fourier domain optical coherence tomography

Fourier or spectral domain optical coherence tomography (FDOCT) is a multi-dimensional interferometric imaging modality that has attracted increasing interest during the last few years. The reason is its outstanding sensitivity allowing high speed 2D and 3 ...

EPFL2007

Novel CMOS Analog Signal Processing Technique for Solid-State X-Ray Sensors in Medical Imaging Systems

Rafal Tomasz Dlugosz

Ability to peer into human body is an essential diagnostic tool in medicine. Out of the four major imaging modalities that include ultra-sound, magnetic resonance imaging (MRI), and positron emission tomography (PET), nuclear medicine is gaining more wides ...

2007

Longitudinally polarized fields in near-field imaging systems

The evolution path of nanotechnologies moves through the domain of microscopy. Among all the kinds of imaging tools available today, optical imaging systems are of primary importance. When using optical imaging systems, we take profit of the information re ...

Institut de Microtechnique, Université de Neuchâtel2006