Big BangThe Big Bang event is a physical theory that describes how the universe expanded from an initial state of high density and temperature. Various cosmological models of the Big Bang explain the evolution of the observable universe from the earliest known periods through its subsequent large-scale form. These models offer a comprehensive explanation for a broad range of observed phenomena, including the abundance of light elements, the cosmic microwave background (CMB) radiation, and large-scale structure.
Glutamic acidGlutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can synthesize enough for its use. It is also the most abundant excitatory neurotransmitter in the vertebrate nervous system. It serves as the precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons. Its molecular formula is C5H9NO4.
Cauchy sequenceIn mathematics, a Cauchy sequence, named after Augustin-Louis Cauchy, is a sequence whose elements become arbitrarily close to each other as the sequence progresses. More precisely, given any small positive distance, all but a finite number of elements of the sequence are less than that given distance from each other. It is not sufficient for each term to become arbitrarily close to the term. For instance, in the sequence of square roots of natural numbers: the consecutive terms become arbitrarily close to each other – their differences tend to zero as the index n grows.
Insertion (genetics)In genetics, an insertion (also called an insertion mutation) is the addition of one or more nucleotide base pairs into a DNA sequence. This can often happen in microsatellite regions due to the DNA polymerase slipping. Insertions can be anywhere in size from one base pair incorrectly inserted into a DNA sequence to a section of one chromosome inserted into another. The mechanism of the smallest single base insertion mutations is believed to be through base-pair separation between the template and primer strands followed by non-neighbor base stacking, which can occur locally within the DNA polymerase active site.
Substitution matrixIn bioinformatics and evolutionary biology, a substitution matrix describes the frequency at which a character in a nucleotide sequence or a protein sequence changes to other character states over evolutionary time. The information is often in the form of log odds of finding two specific character states aligned and depends on the assumed number of evolutionary changes or sequence dissimilarity between compared sequences. It is an application of a stochastic matrix.
Salt Lake CitySalt Lake City, often shortened to Salt Lake or SLC, is the capital and most populous city of Utah, United States. It is the seat of Salt Lake County, the most populous county in Utah. With a population of 200,133 in 2020, it is the 117th most populous city in the United States, the city is the core of the Salt Lake City metropolitan area, which had a population of 1,257,936 at the 2020 census.
