A unified framework for evaluating non-visual spectral effectiveness of ocular light exposure: key concepts
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The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...
In addition to stimulating visual responses, light induces a range of circadian, neuroendocrine and neurobehavioral non-visual responses in humans. These effects are mediated primarily via a novel non-rod, non-cone photoreceptor, which is most sensitive to ...
RPE65-related Leber's congenital amaurosis (LCA) is a rod-cone dystrophy whose clinical outcome is mainly attributed to the loss of rod photoreceptors followed by cone degeneration. Pathogenesis in Rpe65-/- mice is characterized by a slow and progressive d ...
PURPOSE. To characterize in detail the phenotype of five unrelated families with autosomal dominant bull's eye maculopathy (BEM) due to the R373C mutation in the PROM1 gene. ...
Congenital stationary night blindness (CSNB) is a heterogeneous retinal disorder characterized by visual impairment under low light conditions. This disorder is due to a signal transmission defect from rod photoreceptors to adjacent bipolar cells in the re ...
The discovery of a novel non-rod, non-cone photoreceptor in the human eye that mediates a number of effects on the brain has sparked a growing interest in incorporating these non-visual effects of light into the design process of buildings. Appropriately–t ...
Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases that affect the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are preferen ...
The discovery of a novel type of photoreceptor that mediates non-visual light responses in humans has sparked a growing interest in the role of lighting design on human health and wellbeing. Researchers have identified intensity, spectrum, duration/pattern ...
The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors. The nucle ...
Lighting is one of the most significant factors in the built environment that affect human health and wellbeing. In addition to stimulating visual responses, light induces a range of non-visual responses in humans including synchronizing circadian rhythms ...