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Aqueous Titanium Trichloride Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine
Related concepts (25)
Titanium
Titanium is a chemical element with the symbol Ti and atomic number 22. Found in nature only as an oxide, it can be reduced to produce a lustrous transition metal with a silver color, low density, and high strength, resistant to corrosion in sea water, aqua regia, and chlorine. Titanium was discovered in Cornwall, Great Britain, by William Gregor in 1791 and was named by Martin Heinrich Klaproth after the Titans of Greek mythology.
Sonogashira coupling
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It employs a palladium catalyst as well as copper co-catalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide. R1: aryl or vinyl R2: arbitrary X: I, Br, Cl or OTf The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon–carbon bonds.
Turing reduction
In computability theory, a Turing reduction from a decision problem to a decision problem is an oracle machine which decides problem given an oracle for (Rogers 1967, Soare 1987). It can be understood as an algorithm that could be used to solve if it had available to it a subroutine for solving . The concept can be analogously applied to function problems. If a Turing reduction from to exists, then every algorithm for can be used to produce an algorithm for , by inserting the algorithm for at each place where the oracle machine computing queries the oracle for .
Many-one reduction
In computability theory and computational complexity theory, a many-one reduction (also called mapping reduction) is a reduction which converts instances of one decision problem (whether an instance is in ) to another decision problem (whether an instance is in ) using an effective function. The reduced instance is in the language if and only if the initial instance is in its language . Thus if we can decide whether instances are in the language , we can decide whether instances are in its language by applying the reduction and solving .
Amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the α-amino acids, from which proteins are composed. Only 22 α-amino acids appear in the genetic code of all life. Amino acids can be classified according to the locations of the core structural functional groups, as alpha- (α-), beta- (β-), gamma- (γ-) or delta- (δ-) amino acids; other categories relate to polarity, ionization, and side chain group type (aliphatic, acyclic, aromatic, containing hydroxyl or sulfur, etc.
Log-space reduction
In computational complexity theory, a log-space reduction is a reduction computable by a deterministic Turing machine using logarithmic space. Conceptually, this means it can keep a constant number of pointers into the input, along with a logarithmic number of fixed-size integers. It is possible that such a machine may not have space to write down its own output, so the only requirement is that any given bit of the output be computable in log-space. Formally, this reduction is executed via a log-space transducer.
Organopalladium chemistry
Organopalladium chemistry is a branch of organometallic chemistry that deals with organic palladium compounds and their reactions. Palladium is often used as a catalyst in the reduction of alkenes and alkynes with hydrogen. This process involves the formation of a palladium-carbon covalent bond. Palladium is also prominent in carbon-carbon coupling reactions, as demonstrated in tandem reactions. 1873 - A. N. Zaitsev reports reduction of benzophenone over palladium with hydrogen.
Nernst equation
In electrochemistry, the Nernst equation is a chemical thermodynamical relationship that permits the calculation of the reduction potential of a reaction (half-cell or full cell reaction) from the standard electrode potential, absolute temperature, the number of electrons involved in the redox reaction, and activities (often approximated by concentrations) of the chemical species undergoing reduction and oxidation respectively. It was named after Walther Nernst, a German physical chemist who formulated the equation.
Essential amino acid
An essential amino acid, or indispensable amino acid, is an amino acid that cannot be synthesized from scratch by the organism fast enough to supply its demand, and must therefore come from the diet. Of the 21 amino acids common to all life forms, the nine amino acids humans cannot synthesize are valine, isoleucine, leucine, methionine, phenylalanine, tryptophan, threonine, histidine, and lysine.
Reduction potential
Redox potential (also known as oxidation / reduction potential, ORP, pe, , or ) is a measure of the tendency of a chemical species to acquire electrons from or lose electrons to an electrode and thereby be reduced or oxidised respectively. Redox potential is expressed in volts (V). Each species has its own intrinsic redox potential; for example, the more positive the reduction potential (reduction potential is more often used due to general formalism in electrochemistry), the greater the species' affinity for electrons and tendency to be reduced.