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Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

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Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

Bruno Lemaitre, Maroun Bou Sleiman, Wen Bin Chng

Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in n ...

Elsevier2014

Measurement of Long-Chain Fatty Acid Uptake into Adipocytes

Grigory Karateev

The ability of white and brown adipose tissue to efficiently take up long-chain fatty acids is key to their physiological functions in energy storage and thermogenesis, respectively. Several approaches have been taken to determine uptake rates by cultured ...

Elsevier Academic Press Inc2014

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...

Springer Basel Ag2014

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Hepatic glucose sensing is required to preserve β cell glucose competence

Rolf Gruetter, Bernard Lanz, Frédéric Schütz, Carole Poitry-Yamate

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

The brain has very high energy demands that are mainly met by the circulating blood glucose to ensure its proper functioning. Thus, it is not surprising that though the human brain weighs only 2- 3% of the body weight, it consumes approximately 25% of tota ...

EPFL2013

According to the World Health Organization worldwide obesity has more than doubled since 1980. The World health statistics 2012 report shows that one in six adults is obese, one in ten diabetic and one in three has a raised blood pressure. Overweight and o ...

EPFL2013

The Digestive Tract of Drosophila melanogaster

Bruno Lemaitre

The digestive tract plays a central role in the digestion and absorption of nutrients. Far from being a passive tube, it provides the first line of defense against pathogens and maintains energy homeostasis by exchanging neuronal and endocrine signals with ...

2013

The Digestive Tract of Drosophila melanogaster

Bruno Lemaitre

Annual Reviews2013

Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions

Martin Kussmann, Krisztina Nagy

BACKGROUND/OBJECTIVES: The vitamin E derivative, alpha-tocopheryl acetate, is often included in formulations used in enteral nutrition. In this respect, we compared alpha-tocopherol and alpha-tocopheryl acetate absorption under 'maldigestion' conditions, s ...

Nature Publishing Group2013