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A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants

Related publications (37)

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

Cancer is a global disease and a leading cause of death worldwide. While surgery, radiotherapy and chemotherapy comprise the classical tools to eradicate tumors, they do not cure cancer, cannot prevent metastases, lead to side effects, and most importantly ...

EPFL2013

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Stephane Kontos, Jeffrey Alan Hubbell, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Susan Thomas, Amine Issa, Vidya Raghavan

Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...

Elsevier2012

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

Iraklis Kourtis

Cancer is a leading cause of death worldwide. Understanding the underlying mechanisms that lead to tumor escape and evasion is pivotal for the design of new therapeutic applications. This thesis takes an immunobioengineering approach, and navigates through ...

EPFL2012

Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model

Heidi Fournier

Tumor microenvironment contributes strongly to tumor evolution toward metastasis, a final stage in cancer progression. It provides essential clues to promote migration of cancer cells in metastatic sites. Moreover, inflammatory cells and immunomodulatory m ...

2011

Cytotoxic effect of a polymer-copper(II) complex containing 2,2 '-bipyridyl ligand on human lung cancer cells

The cytotoxic activity of the polymer-copper(II) complex, [Cu(bpy)(2)(BPEI)]Cl-2 center dot 4H(2)O (bpy = 2,2'-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techni ...

2011

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Mathematical Modeling of T-Cell Experimental Data

Irina Baltcheva

T lymphocytes (T cells) are key components of the adaptive immune system. These cells are able to recognize an enormous variety of pathogens thanks to the great specificity of their trans-membrane proteins, the T cell receptors (TCRs). TCR diversity is cre ...

EPFL2010

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

Alice Anna Tomei

The goals of tissue engineering include recapitulating specific tissue functions for regenerative medicine and developing in vitro models of human tissues to study human physiology and pathophysiology and for testing and screening drugs before expensive cl ...

EPFL2008

Interleukin-2 mastering regulation in cancer and autoimmunity

Ricardo Pérez Suárez, Livan Bladimir Alonso Sarduy

Autoimmunity and tumor immunity evolved as two distinct arenas in immunological research. However, the identification of self-antigens as the major components of malignant cells may define a central role for autoimmunity in cancer control tuned by peripher ...

2007

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