MetastasisMetastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely.
Renal cell carcinomaRenal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases. RCC occurrence shows a male predominance over women with a ratio of 1.5:1. RCC most commonly occurs between 6th and 7th decade of life. Initial treatment is most commonly either partial or complete removal of the affected kidney(s).
Timeline of knowledge about galaxies, clusters of galaxies, and large-scale structureThe following is a timeline of galaxies, clusters of galaxies, and large-scale structure of the universe. 5th century BC — Democritus proposes that the bright band in the night sky known as the Milky Way might consist of stars. 4th century BC — Aristotle believes the Milky Way to be caused by "the ignition of the fiery exhalation of some stars which were large, numerous and close together" and that the "ignition takes place in the upper part of the atmosphere, in the region of the world which is continuous with the heavenly motions".
Velocity dispersionIn astronomy, the velocity dispersion (σ) is the statistical dispersion of velocities about the mean velocity for a group of astronomical objects, such as an open cluster, globular cluster, galaxy, galaxy cluster, or supercluster. By measuring the radial velocities of the group's members through astronomical spectroscopy, the velocity dispersion of that group can be estimated and used to derive the group's mass from the virial theorem.
Cell cultureCell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. This technique is also called micropropagation. After the cells of interest have been isolated from living tissue, they can subsequently be maintained under carefully controlled conditions. They need to be kept at body temperature (37 °C) in an incubator.
Pancreatic neuroendocrine tumorPancreatic neuroendocrine tumours (PanNETs, PETs, or PNETs), often referred to as "islet cell tumours", or "pancreatic endocrine tumours" are neuroendocrine neoplasms that arise from cells of the endocrine (hormonal) and nervous system within the pancreas. PanNETs are a type of neuroendocrine tumor, representing about one-third of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Many PanNETs are benign, while some are malignant. Aggressive PanNET tumors have traditionally been termed "islet cell carcinoma".
Epithelial–mesenchymal transitionThe epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types. EMT is essential for numerous developmental processes including mesoderm formation and neural tube formation. EMT has also been shown to occur in wound healing, in organ fibrosis and in the initiation of metastasis in cancer progression.
Stem-cell lineA stem cell line is a group of stem cells that is cultured in vitro and can be propagated indefinitely. Stem cell lines are derived from either animal or human tissues and come from one of three sources: embryonic stem cells, adult stem cells, or induced stem cells. They are commonly used in research and regenerative medicine. Stem cell By definition, stem cells possess two properties: (1) they can self-renew, which means that they can divide indefinitely while remaining in an undifferentiated state; and (2) they are pluripotent or multipotent, which means that they can differentiate to form specialized cell types.
Galaxy groups and clustersGalaxy groups and clusters are the largest known gravitationally bound objects to have arisen thus far in the process of cosmic structure formation. They form the densest part of the large-scale structure of the Universe. In models for the gravitational formation of structure with cold dark matter, the smallest structures collapse first and eventually build the largest structures, clusters of galaxies. Clusters are then formed relatively recently between 10 billion years ago and now.
Trapezium ClusterThe Trapezium or Orion Trapezium Cluster, also known by its Bayer designation of Theta1 Orionis, is a tight open cluster of stars in the heart of the Orion Nebula, in the constellation of Orion. It was discovered by Galileo Galilei. On 4 February 1617 he sketched three of the stars (A, C and D), but missed the surrounding nebulosity. A fourth component (B) was identified by several observers in 1673, and several more components were discovered later like E, for a total of eight by 1888.
