Publications related to Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Daniel Pawel Szlag, Corinne Berclaz, Jérôme Extermann, Joan Goulley

Aims/hypothesis It is generally accepted that structural and functional quantitative imaging of individual islets would be beneficial to elucidate the pathogenesis of type 1 diabetes. We here introduce functional optical coherence imaging (FOCI) for fast, ...

Springer Verlag2016

Device design and materials optimization of conformal coating for islets of Langerhans

Jeffrey Alan Hubbell, Alice Anna Tomei

Encapsulation of islets of Langerhans may represent a way to transplant islets in the absence of immunosuppression. Traditional methods for encapsulation lead to diffusional limitations imposed by the size of the capsules (600-1,000 m in diameter), which r ...

Natl Acad Sciences2014

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Michaël Unser, Daniel Sage, Christophe Bauer

Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...

Springer2013

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Jeffrey Alan Hubbell, Mikaël Martino

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, he ...

Mary Ann Liebert, Inc2013

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Dimitri Nestor Alice Van De Ville, Theo Lasser, Anthony Christopher Davison, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Corinne Berclaz, Joan Goulley, Erica Martin-Williams

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Implantable enzyme amperometric biosensors

Sandro Carrara

The implantable enzyme amperometric biosensor continues as the dominant in vivo format for the detection, monitoring and reporting of biochemical analytes related to a wide range of pathologies. Widely used in animal studies, there is increasing emphasis o ...

2012

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Anders Meibom, Jaroslaw Hubert Stolarski, Isabelle Domart-Coulon, Christophe Kopp

In contrast to siliceous sponge spicules, the biomineralization in calcareous sponges is poorly understood. In particular, the existence of a differentiated central core in calcareous spicules is still controversial. Here we combine high-spatial resolution ...

2011

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Philipp Bucher

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

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Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Device design and materials optimization of conformal coating for islets of Langerhans

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Implantable enzyme amperometric biosensors

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Towards high resolution optical imaging of beta cells in vivo

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Device design and materials optimization of conformal coating for islets of Langerhans

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Towards high resolution optical imaging of beta cells in vivo

Implantable enzyme amperometric biosensors

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression