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Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy
Related publications (61)
Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands
Paul Joseph Dyson, Lucinda Kate Batchelor
The first examples of (arene)Os(II) curcuminoid derivatives have been prepared and characterized. The neutral complexes [(p-cym)Os(curc)Cl] (1) and [( p-cym)Os(bdcurc)Cl] ( 2), together with the cationic derivatives [( p-cym)Os(curc)(PTA)][SO3CF3] (3) and ...
ROYAL SOC CHEMISTRY2019Understanding the interactions of diruthenium anticancer agents with amino acids
Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Muhammad Hanif
The dinuclear anticancer agents 1,n-bis{chlorido3-(oxo-kappa O)-2-methyl-4-(1H)-pyridinonato-kappa O4-ruthenium(II)}alkane (PyRu2n) exhibit high antiproliferative activity in human cancer cell. Reactivity studies with DNA and protein rev ...
SPRINGER2018Synthesis, characterization and cytotoxicity of arene-ruthenium(II) complexes with acylpyrazolones functionalized with aromatic groups in the acyl moiety
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel
A series of neutral ruthenium(II)-arene complexes, [(arene) Ru(Q(R))Cl] (arene = p-cymene or hexamethylbenzene), containing 4-acyl-5-pyrazolonate (Q(R)) ligands with aromatic substituents in the acyl moiety (a phenyl in Q(Ph) and a 1-naphthyl in Q(naph)) a ...
2018alpha-Diimine homologues of cisplatin: synthesis, speciation in DMSO/water and cytotoxicity
Paul Joseph Dyson, Lucinda Kate Batchelor, Silvia Schoch
The Pt(ii) -diimine complexes [PtCl2{N-2-(HCNR)(2)}] (R = C6H11, 1; 4-C6H10OH, 2; 4-C6H4CH3, 3; 4-C6H4OH, 4) and [PtCl2{N-2-(CH3CNOH)(2)}] (5) were prepared in 60-81% yields from the 1:1 molar reactions of cis-[PtCl2(DMSO)(2)] with the appropriate -diimine ...
ROYAL SOC CHEMISTRY2018Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel, Agnese Petrini
A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [CpM(DBM/ HDB/AVB)Cl] and [CpM(DBM/HDB/AVB)(PTA)]-[SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydi- ...
American Chemical Society2017Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo
Paul Joseph Dyson, Patrycja Nowak-Sliwinska
Four diruthenium trithiolato chlorambucil conjugates have been prepared via Steglich esterification from chlorambucil and the corresponding trithiolato precursors. All conjugates are highly cytotoxic towards human ovarian A2780 and A2780cisR cancer cell li ...
Springer Verlag2016(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity
Paul Joseph Dyson, Tina Riedel
Heterobimetallic Ru-Fe complexes of the general formula [(eta(6)-p-cymene) RuCl2(Ph(2)PfcCONHCH(2)CH(2-)COY-kappa P)], where Y = Me, NH2, NHEt, NHPh, and NMe2, and fc = ferrocene-1,1'-diyl, were synthesized from p-cymene ruthenium dichloride dimer and phos ...
Elsevier Science Sa2016p,t-[Ru(CO)(PR3)(tren)](2+) [R=Ph or p-tol; tren=tris(2-aminoethyl)amine], Ru(II) complexes bearing a simple tripodal tetradentate amine: synthesis, characterization, and antimicrobial activity
Paul Joseph Dyson, Rosario Scopelliti, Francisco Dinis Fagundes
Complexes with general formula p,t-[Ru(CO)(PR3)(tren)]X-2 [R=Ph (1) or p-tol (2); tren=tris(2-aminoethyl)amine; X=Cl- or PF6-] were prepared from [RuCl2(CO)(dmf)(PR3)] by direct reaction with tren. The complexes were fully characterized by NMR (H-1, P-31{H ...
Taylor & Francis2016Influence of Elemental Iodine on Imidazolium-Based Ionic Liquids: Solution and Solid-State Effects
Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Felix Daniel Bobbink, Emilia Paunescu
Ionic liquids doped with I-2, usually resulting in the formation of polyiodide anions, are extensively used as electrolytes and in iodination reactions. Herein, NMR spectroscopy and single-crystal X-ray diffraction were used to rationalize the structures o ...
2015