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Protrusion-retraction switches and traction forces in spontaneous cell polarization

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Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Alexander Hooftman

Background Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multitude of factors, including the metabo ...

Basel2023

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

Daniel Molina Romero

Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...

EPFL2023

Principle and Analysis of Radial-Force-Based Swirling Actuator for Low-Speed High-Torque Applications

Adrien Jean-Michel Thabuis

This article proposes a swirling actuator that uses the electromagnetic radial force and mechanical gears to generate rotational torque. The proposed actuator generates a rotating radial force between an inner stator and a swirler. The gears on the swirler ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Analysis and Modeling of the Dynamics of Traction Forces during Cell Polarization and their Role in the Organization of Edge Activity

Zeno Messi

The capacity to break symmetry and organize activity to move directionally is a fundamental property of eukaryotic cells. To explain the organization of cell-edge activity, models commonly rely on front-to-back gradients of functional components or regulat ...

EPFL2021

Progressive Correspondence Pruning by Consensus Learning

Mathieu Salzmann, Chenxu Zhao, Hongwei Li, Feng Zhu, Rui Zhao

Correspondence pruning aims to correctly remove false matches (outliers) from an initial set of putative correspondences. The pruning process is challenging since putative matches are typically extremely unbalanced, largely dominated by outliers, and the r ...

IEEE2021

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

EPFL2021

Embryonic tissues as active foams

Sangwoo Kim

The physical state of embryonic tissues emerges from non-equilibrium, collective interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics of glassy dynamics have all been observed in multicellular systems, but it is ...

2021

Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization

Franck Claude Raynaud, Alicia Carine Bornert, Zeno Messi

Traction forces are generated by cellular actin-myosin system and transmitted to the environment through adhesions. They are believed to drive cell motion, shape changes, and extracellular matrix remodeling [1 -3] . However, most of the traction force anal ...

2020

How single-cell immunology is benefiting from microfluidic technologies

Sebastian Maerkl

The immune system is a complex network of specialized cells that work in concert to protect against invading pathogens and tissue damage. Imbalances in this network often result in excessive or absent immune responses leading to allergies, autoimmune disea ...

2020

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Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...

2020