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Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

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Numerical Assessment of Brain Stroke Follow-Up via Differential Microwave Imaging

Juan Ramon Mosig, Michael Mattes, Mina Bjelogrlic

This paper proposes a numerical assessment of brain stroke follow-up via differential Microwave Imaging. The aim is to follow the evolution of the patient’s stroke growth and location, in order to support decisions in the clinical treatment. We present a f ...

2015

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The identification of biological signatures of diseases will enable the development of new biologically grounded classifications of brain diseases, leading to a new systematic understanding of their causes, and new diagnostic tools. In this paper we presen ...

Springer International Publishing2015

Structural connectomics in brain diseases

Jean-Philippe Thiran, Alessandra Griffa, Patric Hagmann, Philipp Baumann

Imaging the connectome in vivo has become feasible through the integration of several rapidly developing fields of science and engineering, namely magnetic resonance imaging and in particular diffusion MRI on one side, image processing and network theory o ...

Elsevier2013

Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Jérôme Barge, Filippo Piffaretti

Background: Photodynamic therapy (PDT) with Metvix® is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. Objective: W ...

Karger2013

The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields du ...

Molecular Diversity Preservation International2012

Photodynamic therapy (PDT) is a minimally invasive form of treatment, which is clinically approved for the treatment of angiogenic disorders, including certain forms of cancer and neovascular eye diseases. Although the concept of PDT has existed for a long ...

2012

Explaining the length threshold of polyglutamine aggregation

Paolo De Los Rios, Marc Hafner

The existence of a length threshold, of about 35 residues, above which polyglutamine repeats can give rise to aggregation and to pathologies, is one of the hallmarks of polyglutamine neurodegenerative diseases such as Huntington's disease. The reason why s ...

2012

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Anna Maria Novello, Patrycja Nowak-Sliwinska, Filippo Piffaretti, Cédric Xavier Paulou

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

Spie-Soc Photo-Optical Instrumentation Engineers2012

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The concentration of oxygen and its rate of consumption are important factors in certain medical treatments, such as radiotherapy and photodynamic therapy (PDT). Measuring the tissue concentration of oxygen or its partial pressure (pO2) can be achieved by ...

Schweizerische Chemische Gesellschaft2011

Femtosecond UV Studies of the Electronic Relaxation Processes in Cytochrome c

Majed Chergui, Andrea Cannizzo, Cristina Consani

We report on an experimental study with UV and visible ultrafast time-gated emission and transient absorption of the early photodynamics of horse heart Cytochrome c in both ferric and ferrous redox states. A clear separation in time and energy of tryptopha ...

2011