Kinetic isotope effects for fast deuterium and proton exchange rates
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The phenomenon of magnetism is one of the key components of today's technological progress. Magnetic interactions and magnetic materials are essential for the scientific disciplines of physics, chemistry and biology, making this subject truly multidiscipli ...
We report site-resolved observation of hydrogen exchange in the micro-crystalline protein Crh. Our approach is based on the use of proton T-2(')-selective H-1-C-13-C-13 correlation spectra for site-specific assignments of carbons nearby labile protein prot ...
The heterotritopic ligand [bpy(DTTA)2]8- has two diethylenediamine-tetraacetate units for selective lanthanide(III) coordination and one bipyridine function for selective FeII coordination. In aqueous solution and in the presence of these metals, the ligan ...
By implementing new NMR methods that were designed to map very slow exchange processes we have investigated and characterized the refolding kinetics of a thermodynamically stable 34mer RNA sequence in dynamic equilibrium. The RNA sequence was designed to u ...
Since many biological processes occur on the μs to ms time scale, internal dynamics on that time scale is believed to be related to biological functionality. The characterization of internal dynamics is thus an important issue to improve our understanding ...
Since many biological processes occur on the μs to ms time scale, internal dynamics on that time scale may well be related to biological functionality. The characterization of internal dynamics is thus an important issue to improve our understanding of the ...
This paper investigates whether monetary and exchange rate policies are important for the success of major fiscal adjustments. We assess their role controlling for other determinants of success identified in the literature, including the size and compositi ...
A pulsed field gradient NMR (= nuclear magnetic resonance) method using stimulated echoes for determining the translational isotropic or anisotropic diffusion coefficient of a molecule or supramolecular assembly or the flow rate and direction of fluids con ...
In my thesis I shall focus on the development of new NMR experimental methods to study structure and internal motions of two kinds of biological polymers, viz. proteins and nucleic acids. I shall investigate the anisotropic local motions of peptide planes ...
Exchange transferred effects in soln.-state NMR expts. allow one to det. the conformation of ligands that are weakly bound to macromols. Exchange-transferred nuclear Overhauser effect spectroscopy (TR-NOESY) provides information about internuclear distance ...