Publication
Cortical neurons gradually attain a post-mitotic state
Related publications (38)
Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper
Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...
ELSEVIER IRELAND LTD2022Axon regeneration and circuit reorganization after complete spinal cord injury
First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant
functional benefits can be achieved with lumbosacral neuromodulation and reorganized
spared projections. However, complete spinal cord injuries (SCI) wholly ...
EPFL2019The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells
Precise spatiotemporal regulation of gene expression is essential for development and homeostasis of complex organisms. This is achieved in large part by sequence-specific transcription factors (TF) that bind to genomic regulatory elements to activate or r ...
EPFL2019Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveilla ...
Springer2019Dynamics of protein synthesis and degradation through the cell cycle
David Michael Suter, Andrea Brigitta Alber
Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G(0)) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, global prot ...
TAYLOR & FRANCIS INC2019Two-photon calcium imaging of neocortical projection neurons in whisker somatosensory cortex during goal-directed sensorimotor learning
Abstract
Excitatory projection neurons of the neocortex are thought to play important roles in per-ceptual and cognitive functions of the brain by directly connecting diverse cortical and subcortical areas. However, many aspects of the anatomical and func ...
EPFL2018Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone
Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To ...
2018Ramsey-mode Rb cell clock demonstration with a 3D-printed microwave cavity
We demonstrate operation of a Ramey-mode Rb vapor-cell atomic clock based on a microwave cavity realized by additive manufacturing (3D-printing). The cavity design is based on a loop-gap approach and its critical electrode structure is realized in one mono ...
2018Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and di ...
Cell Press2017Mechanisms of centrosome separation in C. elegans
Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...
EPFL2016