Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior
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A challenge for neurobiology is to integrate information across many levels of research, ranging from behaviour and neuronal networks to cells and molecules. The rodent whisker signalling pathway to the primary somatosensory neocortex with its remarkable s ...
The mammalian neocortex is one of the most complex brain areas, integrating all sensory modalities and allowing the animal to perform high level cognitive operations. Despite some cytoarchitectural specializations, the general neocortical structure is rema ...
Integration of multimodal information is essential for the integrative response of the brain and is thought to be accomplished mostly in sensory association areas. However, available evidences in humans and monkeys indicate that this process begins already ...
In healthy subjects, preparation to move is accompanied by motor cortical disinhibition. Poor control of intracortical inhibitory function in the primary motor cortex (M1) might contribute to persistent abnormal motor behavior in the paretic hand after chr ...
Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...
Huntington's disease is an autosomal dominant inherited neurodegenerative disease with motor symptoms that are variably co-expressed with mood and cognitive symptoms, and in which variable neuronal degeneration is also observed in the basal ganglia and the ...
One remarkable aspect of the human motor repertoire is the multitude of bimanual actions it contains. Still, the neural correlates of coordinated movements, in which the two hands share a common goal, remain debated. To address this issue, we designed two ...
Classical studies of mammalian movement control define a prominent role for the primary motor cortex. Investigating the mouse whisker system, we found an additional and equally direct pathway for cortical motor control driven by the primary somatosensory c ...
The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...
Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Previous structural MRI studies have identified regional abnormalities in grey matter, especially in the basal ganglia. These findings are c ...