1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)
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Metallo-beta-lactamases (M beta Ls) are Zn(II)-based bacterial enzymes that hydrolyze beta-lactam antibiotics, hampering their beneficial effects. In the most relevant subclass (B1), X-ray crystallography studies on the enzyme from point to either two zinc ...
Oxalate decarboxylase (OxDC) catalyzes the Mn-dependent conversion of the oxalate monoanion into CO2 and formate. EPR-based strategies for investigating the catalytic mechanism of decarboxylation are complicated by the difficulty of assigning the signals a ...
Microbial production of desired compounds provides an efficient framework for the development of renewable energy resources. To be competitive to traditional chemistry, one requirement is to utilize the full capacity of the microorganism to produce target ...
Proteins are among the central elements in every living cell as these ultimately determine how the cell functions. The protein abundances can be regulated at many levels, such as transcription, translation and degradation. As the complexity increases when ...
Several important societal and economic world problems can be addressed by the smart use of technology. The past 40 years have witnessed the realization of computational systems and networks, rooted in our ability to craft complex integrated circuits out o ...
Stochastic models of biological networks properly take the randomness of molecular dynamics in living cells into account. Numerical solution approaches inspired by computational methods from applied probability can efficiently yield accurate results and ha ...
Several important societal and economic world problems can be addressed by the smart use of technology. The last forty years have witnessed the realization of computational systems and networks, rooted in our ability of crafting complex integrated circuits ...
Several important societal and economic world problems can be addressed by the smart use of technology. The last forty years have witnessed the realization of computational systems and networks, rooted in our ability of crafting complex integrated circuits ...
Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryoni ...
One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) forma class of endogenous 19–23-nucleotide RNAs that can have im ...