Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study
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One important challenge of microsystems design is the implementation of miniaturized actuation principles efficient at the micro-scale. Shape memory alloys (SMAs) have early on been considered as a potential solution to this problem as these materials offe ...
One important challenge of microsystems design is the implementation of miniaturized actuation principles efficient at the micro-scale. Shape memory alloys (SMAs) have early on been considered as a potential solution to this problem as these materials offe ...
In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...
We introduce a preconditioner for the solution of the Bidomain system governing the propagation of action potentials in the myocardial tissue. The Bidomain model is a degenerate parabolic set of nonlinear reaction-diffusion equations. The nonlinear term de ...
Stretch-elicited intracellular calcium (Ca(2+)) changes in individual smooth muscle cells in a ring of aorta were measured simultaneously with the force developed by the ring. A phasic increase in Ca(2+) was observed in 30% of the cells and a sus ...
Neurons in the central nervous system, and in the cortex in particular, are subject to a barrage of pulses from their presynaptic populations. These synaptic pulses are mediated by conductance changes and therefore lead to increases or decreases of the neu ...
The propagation of electric activity inside a realistically-shaped, thick-walled model of the atria was studied. The membrane kinetics was based on the formulations of Courtemanche, Ramirez and Nattel. In spite of the assumed uniformity of all kinetics par ...
To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane ...
Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...
Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...