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Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine
Related publications (46)
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Henry Markram, Rodrigo de Campos Perin
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024A theory of memory consolidation and synaptic pruning in cortical circuits
Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...
EPFL2023Plasticity of sensory representations in the posterior insular cortex during fear learning
Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...
EPFL2023Prefrontal engrams of long-term fear memory perpetuate pain perception
A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...
NATURE PORTFOLIO2023An instance-based learning approach for evaluating the perception of ride-hailing waiting time variability
Michel Bierlaire, Nejc Gerzinic
Understanding user’s perception of service variability is essential to discern their overall perception of any type of (transport) service. We study the perception of waiting time variability for ride-hailing services. We carried out a stated preference su ...
2023Epigenetic memory aids: Synaptic and molecular effects of HDAC inhibition that support memory formation
Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...
EPFL2022The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning
Johannes Gräff, Allison Marie Burns, Jose Vicente Sanchez Mut, Giulia Santoni
Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...
2022Epigenetic plasticity as a signature for memory allocation
Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...
EPFL2022Inquiring the librarian about the location of memory
Where memories are stored in the brain is an age-old question in psychology and neuroscience alike. In particular, whether hippocampus-encoded memories are transferred to the cortex or remain hippocampus-dependent over time has not been definitely answered ...
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD2022Morphological Sensitivity and Falling Behavior of Paper V-Shapes
Behavioral diversity seen in biological systems is, at the most basic level, driven by interactions between physical materials and their environment. In this context we are interested in falling paper systems, specifically the V-shaped falling paper (VSFP) ...
MIT PRESS2022