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Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Related publications (38)

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Arterial remodeling using a constituent-based approach

Alkiviadis Tsamis

This thesis is intended to contribute to the field of biomechanics of growth and remodeling of arteries. The work focuses particularly on growth and remodeling caused by sustained hypertension, increased blood flow, and ageing. A structure-based constituti ...

EPFL2010

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

Regulation of arginase pathway in response to wall shear stress

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Paolo Silacci, Tyler Nerton Thacher, Veronica Gambillara, Fabienne Riche

Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including ather ...

2009

Modulation of arginase pathway by hemodynamic forces

Fabienne Riche

It is well recognized that alterations on wall shear stress plays an important role on the development of atherosclerosis disease. It is known that oscillatory shear stress (OSS) flow pattern induces endothelial dysfunction via changes on nitric oxide (NO) ...

2008

Biomechanical analysis of cerebral arteries

Edouard Fonck

The intent of this thesis is to study the function of elastin in cerebral arteries, its contribution into the aging process and its implication into different cerebral diseases and in particular cerebral aneurysms. As of today, little is known on the genes ...

EPFL2008

Vascular physiology

Sylvain Roy

This thesis aims at better understanding the role played by vascular smooth muscle cells (VSM) in the biomechanics of the arterial wall. Current models assume that under maximal vasodilation VSM carry no load, or the so-called "active stress" is zero. Biom ...

EPFL2008

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Veronica Gambillara

Introduction: Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease i ...

2007

Effect of intimal shear and cyclic strech on arterial segments perfused in vitro

Veronica Gambillara

Hemodynamics have crucial role in the control of vascular tone, in the regulation of arterial remodeling, and in the production of mediators that maintain arterial function. Changes in hemodynamics forces induce profound alterations in vascular cell metabo ...

EPFL2005

Arterial in vitro remodeling

Gabriela Montorzi Thorell

Vascular remodeling is defined as any enduring change in the size and composition of an adult blood vessel, allowing adaptation or repair. The vascular remodeling response has been shown to depend on a variety of endogenous and environmental factors. Physi ...

EPFL2004

Automated Parameterization and Patching of Bifurcating Vessels

Recent developments in computational modeling of human arteries have opened the possibility of performing subject-specific analyses on increasingly larger numbers of subjects. This achievement will eventually lead to a better understanding of the role of g ...

2003