Publication
Does Proton Conduction in the Voltage-Gated H+ Channel hHv1 Involve Grotthuss-Like Hopping via Acidic Residues?
Related publications (37)
The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility
Jian Wang, Roman Chrast, Friedrich Beermann, Anne Wilson
The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...
2012High hopes for RANKL: will the mouse model live up to its promise?
The steroid hormones, estrogens and progesterone are key drivers of postnatal breast development and are linked to breast carcinogenesis. Experiments in the mouse mammary gland have revealed that they rely on paracrine factors to relegate their signal loca ...
BioMed Central2011One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
Recently discovered bacterial homologues of eukaryotic pentameric ligand-gated ion channels, such as the Gloeobacter violaceus receptor (GLIC), are increasingly used as structural and functional models of signal transduction in the nervous system. Here we ...
National Academy of Sciences2010Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease
Macrophage migration inhibitory factor (MIF) is a major mediator in innate immunity and inflammation and a potential therapeutic target in multiple inflammatory, infectious and autoimmune diseases including cancer. Current therapeutic strategies for target ...
EPFL2010Scanning gate microscopy measurements on a superconducting single-electron transistor
We present measurements on a superconducting single-electron transistor (SET) in which the metallic tip of a low-temperature scanning force microscope is used as a movable gate. We characterize the SET through charge stability diagram measurements and comp ...
2009Conformational dynamics of cationic cys-loop receptors
Understanding the functional dynamics of ligand-gated ion-channels (LGIC's) on the molecular level is the aim of this thesis. Members of the protein family of LGIC's are involved in the fast synaptic signal transmission and thereby play a central role in i ...
EPFL2009Endocrine Disruptors and Breast Cancer
Breast cancer strikes one out of eight women in Switzerland. The increase in breast cancer incidence over the past 70 years parallels an enormous increase of man-made, persistent chemicals in our environment; some of which have endocrine-disrupting propert ...
2008Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors
Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl
Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...
2006Tools to study molecules in high electric fields
This thesis describes the application of the quantum mechanics/molecular mechanics (QM/MM) Car-Parrinello methodology to two systems of high biological interest: (a) The potassium channel KcsA from Streptomyces lividans and (b) The DNA repair enzyme EndoIV ...
EPFL2006