Finding NemoFinding Nemo is a 2003 American computer-animated comedy-drama adventure film produced by Pixar Animation Studios for Walt Disney Pictures. Directed by Andrew Stanton with co-direction by Lee Unkrich, the screenplay was written by Stanton, Bob Peterson, and David Reynolds from a story by Stanton. The film stars the voices of Albert Brooks, Ellen DeGeneres, Alexander Gould, Willem Dafoe, and Geoffrey Rush. It tells the story of an overprotective clownfish named Marlin (Brooks) who, along with a forgetful regal blue tang named Dory (DeGeneres), searches for his missing son Nemo (Gould).
Regulatory sequenceA regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an organism. Regulation of gene expression is an essential feature of all living organisms and viruses. In DNA, regulation of gene expression normally happens at the level of RNA biosynthesis (transcription). It is accomplished through the sequence-specific binding of proteins (transcription factors) that activate or inhibit transcription.
Fibroblast growth factor receptorThe fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia. The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity.
Key (music)In music theory, the key of a piece is the group of pitches, or scale, that forms the basis of a musical composition in Western classical music, art music, and pop music. Tonality (from "Tonic") or key: Music which uses the notes of a particular scale is said to be "in the key of" that scale or in the tonality of that scale. A particular key features a tonic note and its corresponding chords, also called a tonic or tonic chord, which provides a subjective sense of arrival and rest, and also has a unique relationship to the other pitches of the same key, their corresponding chords, and pitches and chords outside the key.
Closely related keyIn music, a closely related key (or close key) is one sharing many common tones with an original key, as opposed to a distantly related key (or distant key). In music harmony, there are six of them: four of them share all the pitches with a key with which it is being compared, one of them share all except one, and one shares the same tonic. Such keys are the most commonly used destinations or transpositions in a modulation, because of their strong structural links with the home key.
