A new optical tool to combine optical and electrical analysis in neuronal drug screening
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In this contribution we present the development of three microfabricated devices for the study of neuronal and cellular networks. Together, these devices form an attractive toolbox, which is useful to stimulate and record signals of both electrical and che ...
PhotoMEA is a biosensor useful for the analysis of an in vitro neuronal network, fully based on optical methods. Its function is based on the stimulation of neurons with caged glutamate and the recording of neuronal activity by Voltage-Sensitive fluorescen ...
Large network monitoring of electrogenic cells by means of micro electrode arrays (MEA) has become a valuable methodology in electrophysiology. In order to understand the mechanisms of learning (plasticity) and memory in fundamental neuroscience it is impe ...
Light stimulation of neurons is a promising approach for investigating the molecular mechanisms at the basis of neuronal physiology and plasticity. In particular, flash photolysis of caged compounds offers the unique advantage of allowing to quickly change ...
A large number of studies on neuronal physiology and plasticity have provided a detailed picture of the molecular machinery underlying the modulation of neuronal activity. On the contrary, the mechanisms controlling properties of complex neuronal networks ...
Reducing the complexity of large systems described as complex networks is key to understanding them and a crucial issue is to know which properties of the initial system are preserved in the reduced one. Here we use random walks to design a coarse graining ...
Numerical simulations of the transient operation of an islanded power network subject to load rejections are performed. The islanded power network case study consists of a 1-GW hydroelectric power plant featuring four generating units, a long penstock, and ...
Understanding how the information is coded in large neuronal networks is one of the major challenges for neuroscience. A possible approach to investigate the information processing capabilities of the neuronal ensembles is given by the use of dissociated n ...
Technological innovations in the fields of biomedical optics and electronics have lead to an extremely high level of miniaturization. These steps opened important perspectives to interface optoelectronic instruments with cellular systems. In this frame, a ...
We propose a new model of small-world networks of cells with a time-varying coupling and study its synchronization properties. In each time interval of length /spl tau/ such a coupling is switched on with probability p and the corresponding switching rando ...