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Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection

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Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats

Dominique Pioletti, Randoald Müller, Bastian Peter

Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate ...

2006

To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane ...

2006

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...

2006

Statistics of subthreshold neuronal voltage fluctuations due to conductance-based synaptic shot noise

Wulfram Gerstner

Neurons in the central nervous system, and in the cortex in particular, are subject to a barrage of pulses from their presynaptic populations. These synaptic pulses are mediated by conductance changes and therefore lead to increases or decreases of the neu ...

2006

Modelling the effect of soil water content and sorption on dye-tracer fluorescence

Fluorescent dye tracers are used to show concentration maps of tracer fronts, plumes and pathways on soil profiles and in monolith cross sections. The physical process of fluorescence from the exposed soil surfaces must be understood in order to retrieve a ...

2005

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In order to decrease the peri-implant bone loss during the life-time of the implant, oral use of anti-osteoporosis drugs (like bisphosphonates) has been suggested. In this study, bone remodeling parameters identified from clinical trials of alendronate wer ...

2004

Reversible site-selective labeling of membrane proteins in live cells

Horst Vogel, Rudolf Hovius, Emmanuel Guignet

Chem. and biol. labeling is fundamental for the elucidation of the function of proteins within biochem. cellular networks. In particular, fluorescent probes allow detection of mol. interactions, mobility and conformational changes of proteins in live cells ...

2004

Mathematical Formulations of Hebbian Learning

Wulfram Gerstner

Several formulations of correlation-based Hebbian learning are reviewed. On the presynaptic side, activity is described either by a firing rate or by presynaptic spike arrival. The state of the postsynaptic neuron can be described by its membrane potential ...

Springer Verlag2002

Role of membrane potential in vasomotion of isolated pressurized rat arteries

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster, Mathieu Lamboley

Vasomotion, the phenomenon of vessel diameter oscillation, regulates blood flow and resistance. The main parameters implicated in vasomotion are particularly the membrane potential and the cytosolic free calcium in smooth muscle cells. In this study, these ...

Elsevier2002

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We describe the design and performance tested during six years of clinical trials of a fluorescence endoscope for the detection and delineation of cancers in several hollow organs. The apparatus is based on the imaging of the laser-induced fluorescence tha ...

1997