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Mapping the function of neuronal ion channels in model and experiment

Related publications (64)

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Multichannel Compressed Sensing via Source Separation for Hyperspectral Images

Pierre Vandergheynst, Mohammad Golbabaee

This paper describes a novel framework for compressive sampling of multichannel signals that are highly correlated across the channels. In this work, we assume few number of independent sources are generating the multichannel observations based on a linear ...

2010

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

Recently discovered bacterial homologues of eukaryotic pentameric ligand-gated ion channels, such as the Gloeobacter violaceus receptor (GLIC), are increasingly used as structural and functional models of signal transduction in the nervous system. Here we ...

National Academy of Sciences2010

Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

Joachim Piguet

Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotin ...

EPFL2010

Collimator

Jürgen Brugger, Kristopher Pataky

The present invention is directed to a collimator that comprises grooves or channels in the submicrometer to micrometer range. The present invention is also related to uses of a collimator and collimator holder as described herein as well as apparatuses co ...

2010

Fabrication of polymer-based micro devices: formulation and study of the paste

Peter Ryser, Thomas Maeder, Nathalie Sophie Adeline Serra, Olivier Gentsch

We investigate in the present work the fabrication of polymer-based micro-fluidic and micro-mechanical devices using sacrificial, resistive/conductive pastes, through a screen-printing process. An organic sacrificial paste is first screen-printed onto a su ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2010

Fabrication of Polymer-Based Micro Devices: Formulation and Study of the Paste

Peter Ryser, Thomas Maeder, Nathalie Sophie Adeline Serra, Olivier Gentsch

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2010

Conformational dynamics of cationic cys-loop receptors

Davor Kosanic

Understanding the functional dynamics of ligand-gated ion-channels (LGIC's) on the molecular level is the aim of this thesis. Members of the protein family of LGIC's are involved in the fast synaptic signal transmission and thereby play a central role in i ...

EPFL2009

How Good are Neuron Models?

Wulfram Gerstner, Richard Naud

Opinions strongly diverge on what constitutes a good model of a neuron. Two lines of thought on this have coexisted for a long time: detailed biophysical models (of the style proposed in 1952 by the physiologists Alan Hodgkin and Andrew Huxley) that descri ...

2009

A Class of Transformations that Polarize Binary-Input Memory less Channels

Satish Babu Korada, Eren Sasoglu

A generalization of Arikan's polar code construction using transformations of the form G(circle times n) where G is an l x l matrix is considered. Necessary and sufficient conditions are given for these transformations to ensure channel polarization. It is ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2009

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

Matteo Dal Peraro

The M2 protein of the influenza A virus is activated by low endosomal pH and performs the essential function of proton transfer into the viral interior. The resulting decrease in pH within the virion is essential for the uncoating and further replication o ...

2009