System for optical detection and imaging of sub-diffraction-limited nano-objects
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Life sciences have a constantly growing need for novel methodological approaches suitable to investigate the intracellular environment with increased temporal and spatial resolutions. Recently, optical near-field probes, such as laser-irradiated pointed me ...
We present the use of a microlens array in combination with a conventional optical microscope set-up for the detection of single nanoparticles (NPs) in fluid medium. Optically transparent dielectric microspheres are patterned in a microfabricated well arra ...
A technique that allows direct optical imaging of nanostructures and determines quantitatively geometric nanofeatures beyond the classical diffraction limit by using high-refractive index glass microspheres is introduced. The glass microsphere is put on a ...
Optofluidics is a tool for synthesizing optical systems, making use of the interaction of light with fluids. In this paper we explore optofluidic mechanisms that have evolved in plants where sunlight and fluidic control combine to define most of the functi ...
We propose and experimentally demonstrate a device in which common-path interferometry combined with off-axis holographic geometry is used to realize a digital holographic camera which can be attached to the camera port of a conventional transmission micro ...
Miniaturized optical systems show often unconventional responses compare to larger systems of the same design. We investigate such new phenomena using microlenses, and demonstrate characteristics beyond the refraction limit of the micro-optical systems. ...
Although reactive oxygen species (ROS) are an inescapable part of every living organism, we are only beginning to understand their functions and mechanics. As of now, we know that ROS are involved in cell signalling, stress-response and defence against pat ...
We demonstrate a high-throughput biosensing device that utilizes microfluidics based plasmonic microarrays incorporated with dual-color on-chip imaging toward real-time and label-free monitoring of biomolecular interactions over a wide field-of-view of > 2 ...
We present a novel optical technique for simultaneously measuring the absorbance and the refractive index of a thin film using an infrared optofluidic probe. Experiments were carried on two different liquids and the results agree with the bibliographical d ...
We present the fabrication of a microlens array which can be integrated into a microfluidic device. In the demonstrated technique, a microwell array is firstly fabricated in a Parylene-C layer by a standard cleanroom process. Afterwards, the optically tran ...