Publication
Novel inhibitors of the enzyme activated factor xii (fxiia)
Related publications (49)
N-Terminal Selective C-H Azidation of Proline-Containing Peptides: a Platform for Late-Stage Diversification
Jérôme Waser, Raphaël Michel Henri Simonet-Davin, Emmanuelle Madeline Dominique Allouche
A methodology for the C-H azidation of N-terminal proline-containing peptides was developed employing only commercially available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at th ...
WILEY-V C H VERLAG GMBH2022Novel inhibitors of kallikrein proteases and uses thereof
Christian Heinis, Alessandro Zorzi, Patrick Andreas Gonschorek
The present invention relates to a cyclic inhibitor of a kallikrein protease comprising or consisting of (I) the peptide (X1 (X2)(X3)R(X4)(X5)(X6)(X7)(X8)(X9)(X10)(X11) (Formula (X)), wherein (X1) is present or absent and, is preferably present, and if pre ...
2021Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification
Jérôme Waser, Eliott Hugo Joran Le Du, Marion Marie-Agnès Garreau
A photoredox-catalyzed oxidative decarboxylative coupling of small peptides is reported, giving access to a variety of N,O-acetals. They were used as intermediates for the addition of phenols and indoles, leading to novel peptide scaffolds and bioconjugate ...
2021A minimalistic cyclic ice-binding peptide from phage display
Harm-Anton Klok, Luciano Andres Abriata, Corey Alfred Stevens, Matthew Gibson, Xudong Kong
Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...
2021In vivo detection of d-amino acid oxidase with hyperpolarized d-[1-C-13]alanine
Rolf Gruetter, Hikari Ananda Infinity Yoshihara, Alice Radaelli
d-amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative deamination of several neutral and basic d-amino acids to their corresponding alpha-keto acids. In most mammalian species studied, high DAO activity is found in the kidney, liv ...
2020Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors
Determination of the amino acid phenylalanine is important for lifelong disease management in patients with phenylketonuria, a genetic disorder in which phenylalanine accumulates and persists at levels that alter brain development and cause permanent neuro ...
2019Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2
Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...
EPFL2018Adsorption Free Energy of Single Amino Acids at the Rutile (110)/Water Interface Studied by Well-Tempered Metadynamics
Single amino acids are present in blood plasma and are the building blocks of larger organic residues. Their interaction with surfaces is therefore crucial for biomedical applications in contact with blood. In this work, we use well-tempered metadynamics t ...
2018Catalytic amino acid production from biomass-derived intermediates
Paul Joseph Dyson, Ning Yan, Yefeng Wang, Shunlin Zhang, Yu Han
Amino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including in food for humans, in animal feed, and as precursors for bio-based plastics, among others. However, the development of efficient chemical ...
National Academy of Sciences2018Atomistic simulation of bio-relevant ionic and organic species interacting with rutile - Towards the understanding of apatite formation
Atomistic simulation methods, namely molecular dynamics and well-tempered metadynamics, are used in this thesis to investigate apatite formation from different aspects. First, ions which are more abundant in SBFs under physiological conditions were identif ...
EPFL2018