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Positional cloning of the zebrafish sauternes gene: A model for congenital sideroblastic anaemia

Related publications (32)

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The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

Giulia Manina

The re-emergence of tuberculosis in recent years led the World Health Organization (WHO) to launch the Stop TB Strategy program. Beside repurposing the existing drugs and exploring novel molecular combinations, an essential step to face the burden of tuber ...

Springer2013

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Reductive dehalogenases are the key enzymes involved in the anaerobic respiration of organohalides such as the widespread groundwater pollutant tetrachloroethene. The increasing number of available bacterial genomes and metagenomes gives access to hundreds ...

Amer Soc Microbiology2013

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A series of bimetallic titanium-ruthenium complexes of general formula (η5-C5H5)(μ-η5:κ1-C5H4(CR12)nPR2R3)TiCl2RuCl2 (n = 0, 1, 2 or 4; R1 = H or Me; R2 = H, Ph, or Cy; R3 = Ph or Cy) have been synthesized, including two novel compds. as wel ...

American Chemical Society2010

Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet

Red blood cell (RBC) parameters such as morphology, volume, refractive index, and hemoglobin content are of great importance for diagnostic purposes. Existing approaches require complicated calibration procedures and robust cell perturbation. As a result, ...

2008

Integrated nanoreactor system

Pierre-Yves Bolinger

This thesis describes a method that allows the production in parallel of nano-reactor systems whose function is controlled by a remote stimulus. The reactors comprise a nested system of lipid vesicles part of which release their content during a thermotrop ...

EPFL2006

Computational discovery of biochemical routes to specialty chemicals

Vassily Hatzimanikatis

A computational framework has been developed for the construction and evaluation of metabolic pathways given input substrates and knowledge of enzyme-catalyzed reactions. Application of the framework creates new and existing routes to both chems. known to ...

2004

Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy

Christian Heinis, Dario Neri

We present a new antibody-directed enzyme prodrug therapy strategy (ADEPT) based on a post-proline cleaving endopeptidase and prodrugs, in which cytotoxic moieties are linked to a proline-contg. peptide. Human prolyl endopeptidase was expressed in Escheric ...

2004

Characterization of embryonic globin genes of the zebrafish

Andrew Charles Oates

Hemoglobin switching is a complex process by which distinct globin chains are produced during stages of development. In an effort to characterize the process of hemoglobin switching in the zebrafish model system, we have isolated and characterized several ...

2003

Reaction mechanism of caspases: Insights from QM/MM Car-Parrinello simulations

Ursula Röthlisberger

Caspases are fundamental targets for pharmaceutical interventions in a variety of diseases involving disregulated apoptosis. Here, we present a quantum mechanics/mol. mechanics Car-Parrinello study of key steps of the enzymic reaction for a representative ...

2003

A computational framework for the discovery of novel biotransformations

Vassily Hatzimanikatis

The large no. of chem. transformations involved in biochem. pathways and the even larger no. of enzymes that catalyze these transformations contribute to the complexity of biol. systems. Anal. of the available genome sequences, as well as results from prio ...

2003