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Discovery, evaluation, and analysis of novel pathways for production of five methyl ethyl ketone precursors

Related publications (33)

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The limited supply of fossil fuels and environmental reasons shifted research in industry and academia towards finding their replacements. An important part of these efforts is focused on a sustainable production of the 2nd generation of biofuels. Among ma ...

2017

Exploring chemodiversity in metabolism towards the selective integration of chemistry into biology

Vassily Hatzimanikatis, Jasmin Maria Hafner, Noushin Hadadi

The availability of different levels of omics data helps us to observe cells with higher resolution and from different perspectives. Consequently, the computational exploration of metabolism gained more importance in the last decade to make sense of newly ...

2017

Identification of the enzymes that determine the robustness of lipid profiles in yeast

Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis, Sofia Tsouka

Lipids play a very important role in cell structure and function, as well as in the physiopathology of many diseases. Maintenance of the lipid profiles should be tightly regulated as it is very important for preserving membrane permeability, cell integrity ...

2017

Design of novel enzyme-catalyzed reactions linked to protein sequences for finding enzyme engineering targets

Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi

A key challenge in metabolic engineering is to find and to improve biosynthetic pathways that lead to the cellular production of a given industrial, pharmaceutical or specialty chemical compound. In many cases, the enzymatic reactions required for bio-prod ...

2017

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Understanding complex responses of metabolic processes in biochemical systems requires the quantitative description of the dynamic interplay between metabolite levels, enzyme levels, and reaction rates. Generation and use of such models is hindered by the ...

2017

Electric-Field-Driven Direct Desulfurization

Klaus Kern, Hagen Klauk, Uta Schlickum, Peter Wahl, Ivan Pentegov, Verena Katharina Schendel

The ability to elucidate the elementary steps of a chemical reaction at the atomic scale is important for the detailed understanding of the processes involved, which is key to uncover avenues for improved reaction paths. Here, we track the chemical pathway ...

Amer Chemical Soc2017

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The production of second generation of biofuels by conversion of inexpensive feedstocks is a basis for future bio-sustainable economy. Among many proposed molecules, methyl ethyl ketone (MEK) emerged as one of the most prominent fuel candidates due to its ...

2017

Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks

Vassily Hatzimanikatis

The increasing availability of large metabolomics datasets enhances the need for computational methodologies that can organize the data in a way that can lead to the inference of meaningful relationships. Knowledge of the metabolic state of a cell and how ...

Elsevier2017

Exploring biochemical pathways for mono-ethylene glycol (MEG) synthesis from synthesis gas

Vassily Hatzimanikatis, Meriç Ataman, Noushin Hadadi

Mono-ethylene glycol (MEG) is an important petrochemical with widespread use in numerous consumer products. The current industrial MEG-production process relies on non-renewable fossil fuel-based feedstocks, such as petroleum, natural gas, and naphtha; hen ...

Academic Press Inc Elsevier Science2017

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In an effort of overcoming the limited availability of fossil energy resources the focus of the research and development in the area of biofuels has moved towards developing the second generation of fuels that should be produced via microbial fermentation. ...

2016