Microdevice for Sedimentation-based Separation of Blood Microsamples at the Point of Collection
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This work reports the demonstration of a thermopneumatic microfluidic actuator used to determine blood coagulation time. In this new system, the detection principle is the obstruction of a microfluidic channel by clotted blood. The sample actuation is done ...
Autofluorescence (AF) imaging is a powerful tool for the detection of (pre-)neoplastic lesions in the bronchi. Several endoscopic imaging systems exploit the spectral and intensity contrast of AF between healthy and (pre-)neoplastic bronchial tissues, yet, ...
Product isolation increasingly becomes a major bottleneck in molecular biotechnology. This is especially the case for the sensitive proteineous substances (recombinant proteins, antibodies) and lately also DNA, usually produced in low concentration. The cu ...
Background and Objectives Microparticles (MPs) are small phospholipid vesicles of less than 1 mu m, shed in blood flow by various cell types. These MPs are involved in several biological processes and diseases. MPs have also been detected in blood products ...
Protein oxidation mechanisms result in a wide array of modifications, from backbone cleavage or protein crosslinking to more subtle modifications such as side chain oxidations. Protein oxidation occurs as part of normal regulatory processes, as a defence m ...
Affinity precipitation was compared to affinity chromatography and batch adsorption as the final purification step in a protocol for the isolation of haemoglobin from human blood. Haptoglobin was the affinity ligand. The first steps on the process were rea ...
Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have been implicated in tumor progression. We recently described a lineage of mouse monocytes characterized by expression of the Tie2 angiopoietin receptor and required for th ...
The range of applications of mathematical modelling in biosciences has recently expanded to encompass problems posed by biomedicine and sport sciences. Topics of interest are for instance the prediction of the response of an athlete to exercise, the pharma ...
There are many elements in plasma that can act as surrogate markers of the physiological well-being of a mouse, thus making the collection of blood and plasma a general technique with many applications in mouse phenotyping. For example, the presence of cer ...
The graft copolymer poly(L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) and its RGD- and RDG-functionalized derivs. (PLL-g-PEG/PEG-peptide) were assembled from aq. solns. on titanium (oxide) surfaces. The polymers were characterized by NMR in order to d ...