Publication

Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons

Related publications (46)

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Inhibitory synaptic plasticity: spike timing-dependence and putative network function

Friedemann Zenke, Tim Vogels

While the plasticity of excitatory synaptic connections in the brain has been widely studied, the plasticity of inhibitory connections is much less understood. Here, we present recent experimental and theoretical findings concerning the rules of spike timi ...

Frontiers Research Foundation2013

Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement

Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Lidia Alonso-Nanclares

Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...

2012

Neocortical layer 5 (L5) pyramidal cells have at least two spike initiation zones: Na(+) spikes are generated near the soma, and Ca(2+) spikes at the apical dendritic tuft. These spikes interact with each other and serve as signals for synaptic plasticity. ...

American Physiological Society2011

Neocortical layer 5 (L5) pyramidal cells have at least two spike initiation zones: Na+ spikes are generated near the soma, and Ca2+ spikes at the apical dendritic tuft. These spikes interact with each other and serve as signals for synaptic plasticity. The ...

2011

Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks

Wulfram Gerstner, Friedemann Zenke, Claudia Clopath, Tim Vogels

Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an expla ...

2011

A history of spike-timing-dependent plasticity

Wulfram Gerstner, Henry Markram

How learning and memory is achieved in the brain is a central question in neuroscience. Key to today’s research into information storage in the brain is the concept of synaptic plasticity, a notion that has been heavily influenced by Hebb’s (1949) postulat ...

2011

Spike-timing dependent plasticity

Wulfram Gerstner

Spike Timing Dependent Plasticity (STDP) is a temporally asymmetric form of Hebbian learning induced by tight temporal correlations between the spikes of pre- and postsynaptic neurons. As with other forms of synaptic plasticity, it is widely believed that ...

2010

Synaptic plasticity across different time scales and its functional implications

Claudia Clopath

Humans and animals learn by modifying the synaptic strength between neurons, a phenomenon known as synaptic plasticity. These changes can be induced by rather short stimuli (lasting, for instance, only a few seconds), yet, in order to be useful for long-te ...

EPFL2009

Endosomal Trafficking Of Ampa-Type Glutamate Receptors

Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as we ...

2009

Phenomenological models of synaptic plasticity based on spike timing

Wulfram Gerstner

Synaptic plasticity is considered to be the biological substrate of learning and memory. In this document we review phenomenological models of short-term and long-term synaptic plasticity, in particular spike-timing dependent plasticity (STDP). The aim of ...

Springer Verlag2008