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Guidelines for Genome-Scale Analysis of Biological Rhythms
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The impressive technological advances in genomic analysis and the significant drop in the cost of genome sequencing are paving the way to a variety of revolutionary applications in modern healthcare. In particular, the increasing understanding of the human ...
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2017Genomic targets and molecular partners of the chromatin regulator KAP1
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Homing endonucleases, such as I-DmoI, specifically recognize and cleave long DNA target sequences (∼20 bp) and are potentially powerful tools for genome manipulation. However, inefficient and off-target DNA cleavage seriously limits specific editing in com ...
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National Academy of Sciences2015The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome
Jacques Fellay, Amalio Telenti, Istvan Bartha, Nimisha Chaturvedi
Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...
Public Library Science2015