Publications related to Novel probes for the non-invasive bioluminescence imaging of mitochondrial membrane potential and dipeptidylpeptidase-4 activity in living animals

REST represses a subset of the pancreatic endocrine differentiation program

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing panc ...

Academic Press Inc Elsevier Science2015

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...

American Diabetes Association2015

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Denis Gillet, Grégory François, Alain Bock

In this paper, the problem of predicting blood glucose concentrations (BG) for the treatment of patients with type 1 diabetes, is addressed. Predicting BG is of very high importance as most treatments, which consist in exogenous insulin injections, rely on ...

Elsevier2015

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Tuberculosis drugs: new candidates and how to find more

Claudia Sala, Ruben Hartkoorn

The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet th ...

2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Kamiar Aminian, Stéphane Armand

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. ...

2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Sandrine Gerber

Many biologically active peptides are protected from general proteolytic degradation by evolutionary conserved prolines (Pro), due to conformational constraints imposed by the Pro residue. Thus the biological importance of prolyl-specific peptidases points ...

2009

Novel probes for the non-invasive bioluminescence imaging of mitochondrial membrane potential and dipeptidylpeptidase-4 activity in living animals

Graph Chatbot

Chat with Graph Search

REST represses a subset of the pancreatic endocrine differentiation program

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Tuberculosis drugs: new candidates and how to find more

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

REST represses a subset of the pancreatic endocrine differentiation program

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Tuberculosis drugs: new candidates and how to find more

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease