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Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection
Related publications (46)
Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences
Rolf Gruetter, Lijing Xin, Nathalie Just, Hanne Frenkel
To date, only a couple of functional MR spectroscopy (fMRS) studies were conducted in rats. Due to the low temporal resolution of 1H-MRS techniques, prolonged stimulation paradigms are necessary for investigating the metabolic outcome in the rat brain duri ...
Elsevier2013Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement
Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Lidia Alonso-Nanclares
Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...
2012Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study
Pierre Magistretti, Christian Depeursinge, Nicolas Pavillon, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Daniel Boss, Corinne Moratal
Digital holographic microscopy (DHM) is a noninvasive optical imaging technique that provides quantitative phase images of living cells. In a recent study, we showed that the quantitative monitoring of the phase signal by DHM was a simple label-free method ...
Society for Neuroscience2011Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System
Hélène Danielle Perreten Lambert
A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...
EPFL2011NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid
Broad-spectrum N-methyl D-aspartate (NMDA) antagonists, although proposed in therapies for several pathologies including Huntington's disease (HD), can produce dramatic side-effects. Thus, the therapeutic potential of subunit selective NMDA receptor antago ...
2011Long-Term Depression at Parallel Fiber to Golgi Cell Synapses
Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...
2010Endosomal Trafficking Of Ampa-Type Glutamate Receptors
Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as we ...
2009Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration
Harald Hirling, Nikita Rudinskiy
Clathrin-dependent endocytosis is mediated by a tightly regulated network of molecular interactions that provides essential protein-protein and protein-lipid binding activities. Here we report the hydrolysis of the alpha- and beta2-subunits of the tetramer ...
American Society for Biochemistry and Molecular Biology2009Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons
Ozgün Gökce, Nikita Rudinskiy, Nicole Déglon
Hippocalcin is a neuronal calcium sensor protein previously implicated in regulating neuronal viability and plasticity. Hippocalcin is the most highly expressed neuronal calcium sensor in the medium spiny striatal output neurons that degenerate selectively ...
Wiley-Blackwell2009Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain
Evolution of the neurochemical profile consisting of 19 metabolites after 30 mins of middle cerebral artery occlusion was longitudinally assessed at 3, 8 and 24 h in 6 to 8 mu L volumes in the striatum using localized H-1-magnetic resonance spectroscopy at ...
Nature Publishing Group2009