Publication
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling
Related concepts (24)
Organogenesis
Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation (the ectoderm, endoderm, and mesoderm) form the internal organs of the organism. The cells of each of the three germ layers undergo differentiation, a process where less-specialized cells become more-specialized through the expression of a specific set of genes. Cell differentiation is driven by cell signaling cascades.
Anamniotes
The anamniotes are an informal group of craniates comprising all fishes and amphibians, which lay their eggs in aquatic environments. They are distinguished from the amniotes (reptiles, birds and mammals), which can reproduce on dry land either by laying shelled eggs or by carrying fertilized eggs within the female. Older sources, particularly before the 20th century, may refer to anamniotes as "lower vertebrates" and amniotes as "higher vertebrates", based on the antiquated idea of the evolutionary great chain of being.
Proper velocity
In relativity, proper velocity (also known as celerity) w of an object relative to an observer is the ratio between observer-measured displacement vector and proper time τ elapsed on the clocks of the traveling object: It is an alternative to ordinary velocity, the distance per unit time where both distance and time are measured by the observer. The two types of velocity, ordinary and proper, are very nearly equal at low speeds. However, at high speeds proper velocity retains many of the properties that velocity loses in relativity compared with Newtonian theory.
Proper acceleration
In relativity theory, proper acceleration is the physical acceleration (i.e., measurable acceleration as by an accelerometer) experienced by an object. It is thus acceleration relative to a free-fall, or inertial, observer who is momentarily at rest relative to the object being measured. Gravitation therefore does not cause proper acceleration, because the same gravity acts equally on the inertial observer. As a consequence, all inertial observers always have a proper acceleration of zero.