Publication
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Related publications (32)
Mechanism of KRAS-driven T cell infiltration in colorectal cancer
Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...
EPFL2023GCN2 adapts protein synthesis to scavenging-dependent growth
Pancreatic cancer cells with limited access to free amino acids can grow by scavenging extracellular protein. In a murine model of pancreatic cancer, we performed a genome-wide CRISPR screen for genes required for scavenging-dependent growth. The screen id ...
2022An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells
Fabien Louis Claude Robert Jammes
Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...
EPFL2021Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Paul Joseph Dyson, Gerardo Turcatti, Fabien Kuttler, Damiano Banfi, Hristo Plamenov Varbanov
Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...
2019