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Scanning near-field optical microscopy with new probes and feedback modes

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Nanoscale local modification of PMMA refractive index by tip-enhanced femtosecond pulsed laser irradiation

Mihai Adrian Ionescu

Tip-enhanced optical effects have enabled a wide palette of nanoscale investigation techniques and recently they were successfully used to modify and manipulate matter with nanoscale spatial resolution. We contribute to this latter area by reporting a viab ...

ELSEVIER2023

The adoption of process analytical technologies by the biopharmaceutical industry can reduce the cost of therapeutic drugs and facilitate investigation of new bioprocesses. Control of critical process parameters to retain critical product quality attribute ...

ELSEVIER2021

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

Mélanie Thérèse Marie Hannebelle

Mycobacterium tuberculosis, the etiological agent for the tuberculosis disease, is a bacterial pathogen thought to infect about a quarter of the global human population. It is the first cause of death among infectious diseases, and is most prevalent in low ...

EPFL2020

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A distributed and dynamic strain sensing system based on frequency-scanning phase-sensitive optical time domain reflectometry is proposed and demonstrated. By utilizing an RF pulse scheme with a fast arbitrary waveform generator, a train of optical pulses ...

2020

Multipole interplay controls optical forces and ultra-directional scattering

Olivier Martin, Karim Achouri, Andrei Kiselev

We analyze the superposition of Cartesian multipoles to reveal the mechanisms underlying the origin of optical forces. We show that a multipolar decomposition approach significantly simplifies the analysis of this problem and leads to a very intuitive expl ...

OPTICAL SOC AMER2020

Simplified Instrument Calibration forWide-FieldFluorescence Resonance Energy Transfer (FRET) Measured by the Sensitized Emission Method

Forster (or fluorescence) resonance energy transfer (FRET) is a quantifiable energy transfer in which a donor fluorophore nonradiatively transfers its excitation energy to an acceptor fluorophore. A change in FRET efficiency indicates a change of proximity ...

2020

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Some preliminary results and experimental details of Near-field Scanning Optical Microscopy (NSOM) operation in liquids have been reported by us earlier(1-4). Here we present the first use of custom made polystyrene/poly (methyl methacrylate) (PMMA) optica ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Super-resolution optical imaging: A comparison

Martinus Gijs, Gergely Huszka

Overcoming the classical diffraction limit in optical microscopy is known to be achievable by a variety of far-field and near-field microscopy techniques. More recently, so-called micro-object-based optical super-resolution microscopy techniques have emerg ...

2019

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We report on a sapphire fiber Raman imaging probe's use for challenging applications where access is severely restricted. Small-dimension Raman probes have been developed previously for various clinical applications because they show great capability for d ...

OPTICAL SOC AMER2019

Long-life plastic optical fiber probes for scanning near-field optical microscope

Giovanni Dietler, Anton Smirnov, Ekaterina Rostova

Nowadays, sharpened glass fiber - made probes attached to a quartz tuning fork (TF) and exploiting the shear force - based feedback are by far the most popular in the field of SNOM. These probes are expensive, very fragile and their fabrication is difficul ...

SPIE-INT SOC OPTICAL ENGINEERING2018