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An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells

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Mechanism of Shiga Toxin Clustering on Membranes

Julian Charles Shillcock

The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, despite th ...

American Chemical Society2017

Fluorescent Probes for Plasma Membrane Proteins Based on Nile Red

Efthymia Prifti

Fluorescent probes are very important in basic research and in medicine, because of their sensitivity, versatility and quantitative capabilities. They allow the imaging of tissues or cellular compartments and the monitoring of biological events in vivo. An ...

EPFL2016

Freestanding Ultrathin Nanoparticle Membranes Assembled at Transient Liquid-Liquid Interfaces

Francesco Stellacci, Stefan Guldin, Zhi Luo, Sergio Allegri, Benjamin Timothée Nicolas Le Ouay

A synthetic route is presented for the realization of ultrathin freestanding nanoparticle membranes that are built of gold nanoparticles protected with trimethoxysilane-bearing ligands. The mechanism relies on interfacial assembly in an oil-water mixture. ...

Wiley-Blackwell2016

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Growing interest in the role of ions as cell death regulators has led to the consideration of K+, which plays a major role in events such as necrosis, apoptosis and osmotic shock. These mechanisms induce effluxes of K+, which can be m ...

RSC Publishing2016

In situ synthesis and simulation of polydisperse amphiphilic membranes

Lida Kanari, Julian Charles Shillcock, Liesbeth Maria L Vanherpe, Guy Antoine Atenekeng Kahou, Juan Pablo Palacios

The field of coarse-grained simulations of biopolymers and membranes has grown rapidly in recent years. Industrial groups manufacture and use polymers in fields as diverse as chemicals processing and personal care products, while academic researchers are i ...

Springer India2015

Single-Molecule Imaging Deciphers the Relation between Mobility and Signaling of a Prototypical G Protein-Coupled Receptor in Living Cells

Horst Vogel, Joachim Piguet, Luc Veya

Lateral diffusion enables efficient interactions between membrane proteins leading to signal transmission across the plasma membrane. An open question is how the spatio-temporal distribution of cell surface receptors influences the transmembrane signaling ...

American Society for Biochemistry and Molecular Biology2015

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The physical and chemical characterization of biological membranes is of fundamental importance for understanding the functional role of lipid bilayers in shaping cells and organelles, steering vesicle trafficking and promoting membrane-protein signaling. ...

Amer Chemical Soc2015

The motion of a deforming capsule through a corner

Lailai Zhu

A three-dimensional deformable capsule convected through a square duct with a corner is studied via numerical simulations. We develop an accelerated boundary integral implementation adapted to general geometries and boundary conditions. A global spectral m ...

Cambridge University Press2015

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...

Wiley-Blackwell2015

Nuclear size changes dynamically during development and has long been observed to correlate with the space surrounding the nucleus, as well as with the volume of the cell. Here we combine an in vitro cell-free system of Xenopus laevis egg extract with micr ...

2015