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A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model

Related publications (35)

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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Paul Joseph Dyson, Christian Hartinger

The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7-phosphaadamantane (RAPTA ...

2015

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Kristina Schoonjans

Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...

Informa Healthcare2014

Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis

Solène Marcelle Françoise Marie Passemard

At present time, cancer is the leading cause of death in developed countries. The medical imaging tools currently used in clinics such as radiology, nuclear magnetic resonance imaging, microscopy and endoscopy are not able to reach the sensitivity necessar ...

EPFL2014

Towards higher precision in instrument guided liver surgery: automatic registration of 3D ultrasound with pre-operative MeVis-CT

Delphine Ribes Lemay, Matthias Peterhans

Purpose Liver cancer is the 5 most common cancer and shows poor prognosis. Surgical removal of liver tumours, the only existing curative treatment, can merely be used in 10-20% of the case. Increasing surgical precision is a key-challenge to give more pati ...

2012

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Norman Lionel Moullan, Eija Riitta Pirinen, Hiroyasu Yamamoto, Taoufiq Harach, Pablo Jose Fernandez Marcos, Ellen Helena Jeninga

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order ...

2012

Cellular homeostasis is maintained by tightly regulated gene networks, controlled notably at the levels of transcription, mRNA processing, and protein post-translational modification and turnover. This thesis focuses on two of these regulatory steps, namel ...

EPFL2011

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablat ...

2010

Ex vivo gene therapy is an interesting alternative to orthotopic liver transplantation (OLT) for treating metabolic liver diseases. In this study, we investigated its efficacy and biosafety in nonhuman primates. Hepatocytes isolated from liver lobectomy we ...

Elsevier2009

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Correct registration between pre-operative high-resolution images and intra-operative data of lower detail is a fundamental requirement in image-guided liver surgery. We propose a multi modality liver model for measuring the accuracy of such registration m ...

Springer2009

More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...

2008