A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model
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Purpose Liver cancer is the 5 most common cancer and shows poor prognosis. Surgical removal of liver tumours, the only existing curative treatment, can merely be used in 10-20% of the case. Increasing surgical precision is a key-challenge to give more pati ...
2012
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Ex vivo gene therapy is an interesting alternative to orthotopic liver transplantation (OLT) for treating metabolic liver diseases. In this study, we investigated its efficacy and biosafety in nonhuman primates. Hepatocytes isolated from liver lobectomy we ...
The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7-phosphaadamantane (RAPTA ...
Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...
At present time, cancer is the leading cause of death in developed countries. The medical imaging tools currently used in clinics such as radiology, nuclear magnetic resonance imaging, microscopy and endoscopy are not able to reach the sensitivity necessar ...
Correct registration between pre-operative high-resolution images and intra-operative data of lower detail is a fundamental requirement in image-guided liver surgery. We propose a multi modality liver model for measuring the accuracy of such registration m ...
